Abstract Details

Title Association of Motor and Non Motor Symptoms Severity with Motor Laterality Asymmetry in Parkinson´s Disease

Topic Movement Disorders

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-044

Objective The aim of this study was to evaluate the predominant laterality of motor symptoms and its relationship with cognition and other Non Motor symptoms (NMS) in Parkinson´s disease (PD).

Background In PD asymmetric motor signs is intriguing and provide a model to evaluate whether asymmetric nigrostriatal degeneration affects the severity of motor symptoms, and NMS.

Design/Methods Nationwide, cross-sectional, multicenter (Coppadis Registry) outpatient PD study. Left PD (LPD) and right PD (RPD) was defined based on the motor UPDRS scale. To include the clinical spectrum of asymmetric PD patients, we considered two groups of patients with mild-moderate and extreme asymmetry. Predominant LPD or RPD with mild-moderate versus extreme asymmetry were compared in terms of dopaminergic drug doses, motor severity (motor UPDRS in the On, Off states), cognition [Parkinson's Disease Cognitive Rating Scale [PD-CRS], NMS [Non-Motor Symptoms Scale (NMSS)], depression-anxiety [(Beck Depression Inventory-II (BDI-II)], Impulse control disorders (QUIP-RS), and quality of life (PDQ-39) scores. Statistical analysis included non parametric comparisons and regression analysis.

Results 694 PD patients (62.2 ± 8.8 years 57.8% males), 307 (44.2%) RPD, 345 (49.7%) LPD, 42 (6.1%) symmetric PD were included. Compared to RPD, LPD had similar age, disease duration, PD-CRS, BDI-II, QUIP-RS scores and levodopa equivalent dose, but higher scores in the UPDRS motor in the Off (p< 0.0001) and On states (p<0.0001), and NMSS (p<0.0001). After adjusting for disease duration, levodopa dose, and age, mild-moderate LPD were more likely to have higher UPDRS motor scores in the off state (OR=2.3, 95% CI 1.2-4.1, p=0.005), and NMS (OR=2.0, 95% CI 1.1-3.6, p=0.01).

Conclusions

These findings suggest that damage to right-hemisphere plays a disproportionately greater role in PD-related motor and overall NMS severity. Better understanding of the mechanisms contributing to lateralization of neurodegeneration will help to develop more targeted therapeutic approaches, taking into account subtypes of PD as a heterogeneous disorder.

Authors/Disclosures
Esther Cubo Delgado, MD, PhD, FAAN (Fundacion Burgos Investigacion Salud CIF G09254616) PRESENTER	Dr. Cubo Delgado has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Dr. Cubo Delgado has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Zambon. Dr. Cubo Delgado has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbvie. The institution of Dr. Cubo Delgado has received research support from Spanish health ministry. The institution of Dr. Cubo Delgado has received research support from European union grant.
	No disclosure on file
	No disclosure on file
Maria S. Escalante Arroyo, MD (Hospital Verge De La Cinta De Tortosa Serv.)	No disclosure on file
	No disclosure on file
Mercedes Pueyo Morleaans, MD (Hospital Universitario de Canarias)	No disclosure on file
Juan C. Martinez-Castrillo, MD, PhD	No disclosure on file
Pilar Sanchez Alonso	Pilar Sanchez Alonso has received personal compensation in the range of $500-$4,999 for serving as a Consultant for zambon. Pilar Sanchez Alonso has received personal compensation in the range of $0-$499 for serving as a Consultant for Bial. The institution of Pilar Sanchez Alonso has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for abbvie. Pilar Sanchez Alonso has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for zambon. Pilar Sanchez Alonso has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for bial. Pilar Sanchez Alonso has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for abbvie.
Marta Blazquez Estrada	Marta Blazquez Estrada has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Pablo Martinez Martin	No disclosure on file
Diego Santos Garcia	Diego Santos Garcia has nothing to disclose.

��ɫ��

��ɫ��