Abstract Details

Title Recent trends in Guillain-Barré Syndrome related hospitalizations, mortality and resource utilization in United States (2006-2014)

Topic General Neurology

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 4-071

Objective We sought to examine trends of GBS related hospitalizations using Nationwide inpatient sample database.

Background There is a paucity of data regarding recent trends of the national estimate of Guillain-Barré Syndrome (GBS) and its impact on US healthcare.

Design/Methods We utilized Nationwide Inpatient Sample (NIS) data from 2006- 2014 and identified hospitalization with GBS (ICD 9 CM code 357.0). Relative change (RI)was calculated using reference values from 2006. P values for trends were generated by Cochrane-Armitage test for categorical variables and simple linear regression for continuous variables.

Results We identified 52,348 patients with primary diagnosis of GBS during our study period (55.3% Male, 70.7% Caucasian) with the estimated overall cost burden of 1.86 billion $ (relative increase of 21.3% since 2006). We observed a relative increase of 17.1% in hospitalization with primary diagnosis of GBS (from 5,455 to 6,390 in 2014, p<0.0001) with declining trends in duration of length of stay (from 11.3 days to 10 days in 2014) and in-hospital mortality (from 1.7% to 1.25%, relative decline of 27.8 %,). We observed an upward trend of hospitalization in groups with Medicare/Medicaid insurance (RI of 10.3%), admission in teaching hospital (RI of 37.5%), Emergent (RI of 7.4%) or weekend admission (RI of 9.1%). We observed increasing trends in utilization of IVIG therapy (From 15.7% to 35.2%in 2014, RI of 111.7%), patient requiring Mechanical ventilation (From 1.4% to 2.3%, RI of 58.7%) and declining trends in Plasma exchange transfusion (16.3% to 15.3%, relative decline of 6.1%).

Conclusions We observed an increasing trend of hospitalization with GBS and mean cost of hospitalization with a decreasing trend in length of stay and in-hospital mortality. Upward trends of hospitalization are seen in teaching hospitals, weekend admissions and IVIG therapy, which suggest the better availability of resources.

Authors/Disclosures
PRESENTER	No disclosure on file
Chirag N. Savani, MD (Tampa General Hospital)	No disclosure on file
Charles D. Schutt, MD (USF Neurology)	Dr. Schutt has nothing to disclose.
Sheyar Amin, MD (University of South Florida)	Dr. Amin has nothing to disclose.
Tejinder Singh, MD (Reading Hospital- Towerhealth- Division of Neurology)	Dr. Singh has nothing to disclose.
	No disclosure on file
Yazan M. Suradi, MD	No disclosure on file

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