Abstract Details

Title Prevalence and Factors Associated with Diabetic Peripheral Neuropathy in Ilorin, North-Central Nigeria.

Topic General Neurology

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 4-074

Objective

We aimed at determining the prevalence of Distal Symmetrical Polyneuropathy (DSP) and Cardiovascular Autonomic Neuropathy (CAN); and risk factors associated with their occurrence among diabetic patients in Ilorin, north-central Nigeria.

Background Peripheral neuropathy contributes significantly to morbidity and mortality among diabetic patients in sub-Saharan Africa. Data on the co-occurrence of DSP and CAN is sparse in sub-Saharan Africa despite the increasing burden of diabetes.

Design/Methods

This was a hospital based cross-sectional study in which 175 consenting diabetic patients were recruited consecutively as participants. We assessed DSP using the Michigan Neuropathy Screening Instrument (MNSI) and a diagnosis of DSP was made with MNSI symptom score ≥7 or physical examination score ≥2. CAN was assessed using a battery of 5 tests of cardiovascular autonomic function; including heart rate variation to deep breathing, valsalva manoeuvre, and blood pressure change to standing. Patients with abnormalities in ≥2 tests were adjudged to have CAN. Univariate and multivariate logistic regression analyses were used to identify risk factors that were associated with occurrence of DSP and CAN.

Results The prevalence of DSP and CAN was 41.7% and 26.9% respectively while 19.4% had both. Presence of systemic hypertension (OR 2.401; 95% CI 1.169- 4.930, P=0.017) and poor glycaemic control (OR 2.957; 95% CI 1.488- 5.878, P=0.002) were independently associated with DSP. Factors found to be independently associated with presence of CAN were presence of systemic hypertension (OR 2.215; 95% CI 1.023- 4.414, P=0.043) and serum creatinine (OR 1.035; 95% CI 1.014- 1.056, P= <0.001).

Conclusions Peripheral neuropathy (DSP and CAN) is a common complication among diabetic patients and thus efforts should be made to prevent their occurrence by intensifying blood pressure and glucose control while regularly assessing renal function and putting in place measures that prevent decline in renal function.

Authors/Disclosures
Abiodun H. Bello, MD (Department of Internal Medicine) PRESENTER	No disclosure on file
Kolawole W. Wahab, MD, FAAN (University of Ilorin Teaching Hospital)	Dr. Wahab has nothing to disclose.
Emmanuel O. Sanya, MD (Univerisity of Ilorin)	No disclosure on file

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