Abstract Details

Title Demographic and Hemodynamic Characteristics of a large Cohort of Patients with Transient Global Amnesia (TGA)

Topic General Neurology

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 4-076

Objective To assess demographic and hemodynamic characteristics of TGA patients in order to identify risk factors of the syndrome.

Background The etiology of transient global amnesia is still a matter of debate. Previous studies refuted a cerebrovascular pathology as they neither found a higher burden of vascular risk factors nor revealed an increased incidence of strokes after TGA.

Design/Methods We reviewed the clinical records and the magnetic resonance imaging time of flight angiographies of 169 TGA patients and compared the findings to an age and sex matched control group of neurological patients.

Results In TGA, 103 patients (60.9%) were female, 66 male (39.1%), the sex ratio was 1.56:1. The average age was 66.8 years; women were about 5 years older than men (68.8 vs. 63.7 years, p<0.001). 49 of 152 patients had a private health insurance, which is a significantly higher proportion compared to a control group of patients with transient ischemic attacks, of whom only 19.8% held such an insurance (OR 1.93, 95% CI 1.31-2.85, p<0.001). The diameter of the right vertebral artery (VA) was significantly smaller in TGA patients (2.06 mm, SD 0.99 vs. 2.31 mm, SD 0.85, p<0.05), whereas the diameter of the right internal carotid artery (ICA) was significantly larger in the TGA group (4.54 mm, SD 0,49 vs. 4.41, SD 0,56, p<0.05). There were no significant differences in the diameters of the other vessels.

Conclusions Our large single centre study identified female sex and a status of private health insurance (vs. public health care) as potential demographic risk factors. Differences in the diameters of the intracranial vessels may argue for a pathophysiologic contribution of hemodynamic factors.

Authors/Disclosures
Ralph Werner, MD (Katholisches Klinikum Koblenz-Montabaur) PRESENTER	No disclosure on file
	No disclosure on file
Johannes C. Wohrle, MD	No disclosure on file

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