Abstract Details

Title MCI and OSA

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 9-022

Objective A retrospective study to evaluate the association of Obstructive Sleep Apnea and Mild Cognitive Impairment.

Background Mild Cognitive Impairment (MCI) is a syndrome that frequently defines a transitional stage between normal aging and dementia. Untreated Obstructive Sleep Apnea (OSA) can worsen the primary cognitive and functional deficit in Alzheimer’s Disease. OSA is a modifiable risk factor. Short term CPAP therapy showed an almost complete reversal of white matter disease, and normalization of attentive, visuospatial learning, and motor performances. If we can diagnose OSA in early stage, we can probably improve cognitive deficits associated with neurodegenerative process. There has been a paucity of research concerning the association of OSA and MCI.

Design/Methods Cross-sectional subgroup analysis study was performed using the data from TriNetx network within a single outpatient practice. Diagnoses of OSA and MCI were based on ICD-10 billings codes. Patients aged 50 and older were reviewed. Prevalence of OSA in the overall clinic population was compared with the prevalence of OSA in patients with MCI.

Results There were 179,992 patients over 50 years of age in the database. Of these, 5460 had an OSA diagnosis (3.3%). 230 had MCI diagnosis and of these 40 patients had OSA diagnosis (17.39%) (p<0.0001).

Conclusions

The result shows eight times higher prevalence of OSA in MCI patients. These data need to be further analysed to confirm diagnoses and examine risk factors that may contribute to these associations.

Authors/Disclosures
Sanskruti Patel, MD (MedStar Georgetown University Hospital) PRESENTER	No disclosure on file
Christina Maxwell, PhD	Dr. Maxwell has received personal compensation for serving as an employee of Sanofi. Dr. Maxwell has stock in Sanofi.
G. P. Gliebus, MD, FAAN (Marcus Neurosciences Institute)	Dr. Gliebus has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai.

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