Abstract Details

Title Subjective Cognitive Impairment: A Clinical and neuropsychological Entity, sustained by a specific Topography of Lesions. The Cingulum Cohort of Marseille, France.

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 9-025

Objective Characterization of SCI by neuropsychology and MRI.

Background Clinicians have focused on the boundaries between cognitive impairment, at the onset of AD and CNI. SCI characterizes pre-clinical AD, defined by normal cognition, with subjective perception of decline, and silently progress of brain lesions. Conversion from MCI to AD-dementia seems to be an inescapable phenomenon with time. SCI transition, characterized by limited tauopathy in temporal cortex, to MCI, is a hot topic.

Design/Methods Comparing 4 groups of subjects (21 CNI, 44 SCI, 32 MCI and 15 light AD) accessed memory consultation. Our 104 subjects have been classified using CDS, total FCRST and ADAS-Cog scales, and evaluated by a neuropsychological protocol. Apo-E 4 status was tested and measures of brain MRI volume was performed with “Brain Visa” and “Volbrain”. “Brain Visa” measures 41 brain-regions volumes in each hemisphere. Each areas volume was normalized (ratio: volume of area/total cranial volume). Statistical data were analyzed by SPSS.

Results

Only right BRODMANN area (BA) 20 (right inferior temporal gyrus) showed a significant atrophy in SCI, compared to CNI (p=0.004), correlated with ADAS-Cog (p=0.033). In MCI compared to SCI there is in addition a right and left BA 31, median parietal cortex (p=0.026). Significant hippocampal atrophy characterizes only AD, compared to NCI (p=0.043). There is a significant difference between SCI and NCI for RAVLT total score (p=0.008), MFQ (p=0.0001) and GDS (p=0.001).

Conclusions SCI represents the earliest stage of pre-clinical AD, a risk factor for future MCI, and the earlier indicator of tauopathy. Entorhinal cortical tau deposition is common in NCI, but association between SCI and right inferior temporal cortical tau deposition, represents a subtle change of insight with the progression of AD-related tauopathy cascade. Characterization of SCI, anatomically and neuropsychologically, allows to participate in defining the earliest phase of AD, wrongly called pre-symptomatic, is sustained by metacognition disorder.

Authors/Disclosures
Nathalie Sambuchi PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Henri D. Becker, MD (General Hospital Pierre Nouveau)	No disclosure on file
Yonas E. Geda, MD (Barrow Neurological Institute)	The institution of Dr. Geda has received research support from NIH.
Bernard F. Michel, MD	No disclosure on file

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