Abstract Details

Title Color Vision Impairment in Prodromal and Dementia Stages of Lewy Body Disease versus Alzheimer’s Disease

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 9-027

Objective To characterize the prognostic value of color vision testing in the diagnosis of dementia with Lewy bodies (DLB).

Background DLB is frequently misdiagnosed as Alzheimer dementia (AD), particularly in its early stages. Initial studies have demonstrated that new-onset color vision impairment (CVI) is common among patients with DLB and may help differentiate DLB from AD. We examined clinical and imaging characteristics associated with CVI in patients with DLB, suspected prodromal Lewy body disease (pro-LBD), AD, and prodromal AD (pro-AD).

Design/Methods We retrospectively reviewed medical records of patients with DLB, pro-LBD, AD, and pro-AD. All patients underwent an online 15-hue color vision arrangement test. Chi-square or Fisher’s exact test were used for categorical variable comparison and Wilcoxon rank-sum test or t-test for continuous variable comparison.

Results

116 patients were included in this study with a median age of 75 years. No significant differences in age or gender existed among patients with DLB (n=62), pro-LBD (n=24), AD (n=24), or pro-AD (n=6). Six individuals (3 DLB, 2 AD, and 1 pro-AD) had a remote history of CVI and were excluded from the final analysis. Sixty-six percent of patients with DLB and 46% of patients with pro-LBD had new-onset CVI. Overall, new-onset CVI was seen in 60% of patients with DLB or pro-LBD compared to 20% of patients with AD or pro-AD (p<.001). Among 23 patients with DLB or pro-LBD who underwent volumetric MRI, patients with CVI (n=12) had significantly lower normative volumetric percentiles in the medial parietal lobe (38th versus 65th percentile; p=0.028) and the primary motor cortex (20th versus 53rd percentile; p = 0.006).

Conclusions CVI demonstrates a prevalence similar to the core diagnostic features of DLB. Pending prospective confirmation, online CVI testing can be a simple and widely accessible tool to help differentiate DLB from AD and improve the accuracy of early diagnosis of DLB.

Authors/Disclosures
Robert Unger (Cleveland Clinic Lerner College of Medicine) PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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