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Abstract Details

Diet during adolescence and association with Multiple Sclerosis in Colombian patients
Multiple Sclerosis
P4 - Poster Session 4 (5:30 PM-6:30 PM)
15-061
To determine whether there is an association between multiple sclerosis (MS) and dietary habits during adolescence in a Colombian population.
MS is the most common demyelinating disease of the central nervous system. Its prevalence varies according to geographical distribution, with both environmental and genetic factors accounting for the variation, in Colombia its prevalence is low. This is the first study describing diet and MS in a Colombian population. 
We performed a case-control study, a questionnaire was designed to assess for dietary habits during adolescence in 87 patients with a diagnosis of MS and 87 healthy controls. Information regarding sunlight exposure, physical activity, personal and family medical history, and hormonal factors was also collected. A blood sample was obtained to measure vitamin D levels and Epstein-Barr virus antibody levels. We then performed bivariate and multivariate analysis with MS status as the outcome.

Cases had a mean age at enrolment of 40.9 years and 65.52% of them were women. 83.9% had relapsing-remitting MS, 6.89% secondary-progressive MS and 4.59% primary-progressive MS. A multivariate analysis showed significant association between fast food and sugary drinks consumption during adolescence and MS (OR 6.14, CI95% 1.68-22.34, p=0.006; OR 3.72, CI95% 1.25-11.09, p=0.018). Dairy products, gluten, meat, alcohol, coffee, seafood, fruits, vegetables, eggs and grains consumption did not have a significant association. As sugary drinks and fast food could be a confounding factor for each other, an additional analysis controlling for both was done and only fast food consumption remained significantly associated with MS (OR 4.94, CI95% 1.29-18.93, p=0.02).

We found that fast food consumption during adolescence was significantly associated with an increased risk of MS. Additional studies should be done to evaluate this association in other regions of Latin America and near the Equator.
Authors/Disclosures
Jaime Toro, MD, FAAN (Universidad El Bosque)
PRESENTER 		Dr. Toro has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Watch Neurology .
Daniel Noriega (Universidad de Los Andes, School of Medicine) No disclosure on file
Jorge Patiño (The University of Texas Health Science Center at Houston) No disclosure on file
Maria I. Reyes-Mantilla, MD (Johns Hopkins University, Neurology) Dr. Reyes-Mantilla has nothing to disclose.
Lisseth E. Burbano, MD, PhD Ms. Burbano has received research support from The 好色先生.
Saul Reyes, MD (The Royal London Hospital) Dr. Reyes has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. Reyes has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for BIIB. Dr. Reyes has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Merck. Dr. Reyes has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Biogen.
David F. Cuellar Giraldo, Jr., MD (Universidad El Bosque) Dr. Cuellar Giraldo has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file
Alejandra Duque Ramirez, MD (University of Chicago) Dr. Duque Ramirez has nothing to disclose.