Abstract Details

Title Multiple Sclerosis Prevalence Rates Within a Healthcare Delivery System in Northern California: A Retrospective, Electronic Health Records-Based Study From 2010 to 2016

Topic Multiple Sclerosis

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-062

Objective To quantify the prevalence of MS in a healthcare delivery system in northern California, USA.

Background Quantifying the prevalence of MS in geographically distinct regions is important to understand its true burden, especially across diverse racial/ethnic populations residing in the same region and with similar access to healthcare.

Design/Methods An electronic health records database from a healthcare system in northern California was used to quantify MS prevalence in adults ≥18 years of age. Individuals who had an International Classification of Disease 9/10 diagnosis of MS between 2010 and 2016 were identified. Overall and annual prevalence rates were based on the total number of patients with encounters during the entire study period and during each year, respectively. Rates were expressed per 100,000 of the population with 95% CI. For comparisons by year, gender, and racial/ethnic groups, rates were age-adjusted using logistic regression.

Results Among 1,508,102 patients in the healthcare system between 2010 and 2016, MS prevalence was 311/100,000 (95% CI: 300–321). There was a significant increase in age-adjusted prevalence from 259/100,000 (95% CI: 249–271) in 2010 to 358/100,000 (95% CI: 344–372) in 2016 (P<0.0001). A 2.3-fold higher, age-adjusted MS prevalence was observed for women versus men (385 and 164 per 100,000, respectively; P<0.0001). Age-adjusted MS prevalence was highest among black women (677/100,000) and lowest among Asian men (50/100,000). There was a numerical increase in prevalence rates from 2010 to 2016 across all gender and racial/ethnic subgroups. However, only non-Hispanic white women, the largest subgroup, showed a significant linear increase in prevalence by year (27 additional cases/100,000/year; P<0.0001).

Conclusions In a healthcare practice-based setting in northern California, MS prevalence differed by gender and race/ethnicity, and was highest among black women. This study suggests that MS prevalence in northern California is increasing, most notably among non-Hispanic white women.

Authors/Disclosures
Robert Romanelli PRESENTER	No disclosure on file
	No disclosure on file
Joseph R. Lacy, MD (Palo Alto Medical Foundation)	No disclosure on file
Alana T. Wong, PhD (Sanofi Genzyme)	No disclosure on file
Lobat Hashemi	No disclosure on file
	No disclosure on file

��ɫ��

��ɫ��