Abstract Details

Title Multiple Sclerosis (MS) and Neuromyelitis optica (NMO): Admission trends, In-hospital Events, Outcomes, Treatment and Regional Differences In Distribution: A study of the National Inpatient Sample 2006-2014

Topic Multiple Sclerosis

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-064

Objective

We try to establish MS and NMO in terms of demographics, in-hospital events, outcomes, treatment regional differences in distribution at the national level.

Background

Not much is known about multiple Sclerosis (MS) and neuromyelitis optica (NMO) admission rates, trends, In-hospital Events, Outcomes, treatment or geographical distribution.

Design/Methods We analyzed NIS database , from 2006 till 2014, to select MS and NMO patients with primary diagnosis (ICD9: 340.0 and 341.0 respectively). MS and NMO patients were compared for demographics, medical co-morbidities, in-hospital complications, APRDRG disease Severity, hospital regional distribution, length of stay(LOS), hospital charges, disposition to long term facility and in-hospital mortality. In multivariate analysis, model was adjusted with age, gender and APRDRG_Severity

Results

Weighted data revealed 2,12,818 hospitalizations due to MS ( 96.4%) and NMO (3.5%) receptively. NMO patients were significantly younger (41.7(± 16.3) vs 44.6(± 13.7), and more commonly female (82.3% versus 73.6%): p = <.0001) as compared to MS patients respectively. NMO patients had higher APRDRG_Severity disability (3.8% versus 1.1%), p <.0001 and more in-hospital complications: p <.0001 compared to MS patients. Both diseases had higher representation in the southern region NMO: 40.9% versus MS: 35.3%, p: 0.1340). NMO patients had longer length of stay (8.1(±10.5 vs 4.5(±5.4), p <.0001) and higher hospital charges (63672.9(± 87398.4) vs 27366.2(±35239.0), <.0001). No difference in in-hospital mortality but NMO patients had higher rate of disposition to long term facility (28.0%) vs (22.0%), p = 0.0012). In multivariate analysis, NMO had higher odds (OR: 1.428, CI: 1.181- 1.728, p = 0.0002) of disposition to long term facility.

Conclusions

Conclusion: We observed NMO patients were younger,more females, had higher odds of long term facility disposition but no difference for in-hospital mortality. Interestingly, NMO patients had higher proportion in South but not statistically significant than MS patients. Further studies are encouraged to explore the reasons for above mentioned differences.

Authors/Disclosures
Mohammad Rauf A. Chaudhry, MD PRESENTER	Dr. Chaudhry has nothing to disclose.
Jiaqi Yao, MD (Baylor Scott and White)	Dr. Yao has nothing to disclose.
Harathi Bandaru, MD	Dr. Bandaru has nothing to disclose.
Mushtaq H. Qureshi, MD	No disclosure on file
Mohammad Ghatali, MD (Texas Tech Health Science Center)	Dr. Ghatali has nothing to disclose.
	No disclosure on file
Rakesh Khatri, MD, FAAN	Dr. Khatri has received personal compensation in the range of $0-$499 for serving as a Survey consultant with Alpha insight . Dr. Khatri has received personal compensation in the range of $0-$499 for serving as a Survey consultant with Survey company .
Darine Kassar, MD	Dr. Kassar has nothing to disclose.
Alberto Maud, MD (Paul L. Foster School of Medicine Texas Tech UHSC El Paso, Texas)	Dr. Maud has nothing to disclose.
Gustavo J. Rodriguez, MD (Gustavo J. Rodriguez)	Dr. Rodriguez has nothing to disclose.
Salvador Cruz-Flores, MD, FAAN (Paul L. Foster School of Medicine Texas Tech University Health Sciences Center)	The institution of Dr. Cruz-Flores has received research support from University of Texas System.

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