Abstract Details

Title MS race: How does speed affect our patients

Topic Multiple Sclerosis

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-083

Objective 1) To analyze the associations between speed measurements (upper extremities, lower extremities and cognition) and global disability, with quality of life (QoL) of patients with multiple sclerosis (PwMS)
2) To determine the predictive value of mentioned variables on the QoL.

Background Beyond the Expanded Disability Status Scale (EDSS), there are other measurements that assess disability in PwMS. The Multiple Sclerosis Functional Composite (MSFC) is a standardized and quantitative assessment mainly used in clinical trials. MSFC measure lower extremities (LE) function, upper extremities (UE) function, and cognitive function, using speed tests. Speed measures have been shown to be sensitive to assess disability in PwMS. On the other hand, QoL measurements are being considered increasingly important with regard to evaluating disease progression and treatment

Design/Methods 52 PwMS were evaluated. LE and UE function were assessed with T25FW and NHPT respectively. Information processing speed with PASAT and SDMT. Health-related Qol with MusiQuol. A descriptive analysis was carried out on all the variables included. Association between all variables were analyzed with Spearman correlation and lineal regression was undertaken to determine which variable predict of QoL

Results Significant associations were found between
SDMT, PASAT, NHPT, EDSS and the following QoL subscales: activities of daily living (ADL) (r:-.557 to .391; p: <.05), psychological well-being (PWB) (r:-.358 to .386; p: <.05) and Symptoms (SPT) (r: -.360 to .454; p: <.05). T25FW correlated with ADL (r: -.377; p: .008). In the regression analysis, the SDMT and PASAT were established as predictors of SPT (R²:.274; p:<.001; β: .523) and PWB (R²: .116; p: .019; β: .340) respectively NHPT were established as predictors of ADL (R²:.325; p: <.001; β.570).

Conclusions We found a robust association between measures of cognitive and UE speed with different aspects of QoL.
Other measures beyond the EDSS should be taken into account for the follow-up of the PwMS.

Authors/Disclosures
Ricardo Alonso PRESENTER	Ricardo Alonso has nothing to disclose.
	No disclosure on file
Berenice Silva	SIlva Berenice has nothing to disclose.
Cecilia Pita	Cecilia Pita has nothing to disclose.
Sandra Vanotti, MD (Biogen Idec)	No disclosure on file
Domingo O. Garcea, MD	No disclosure on file

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