Fifty-seven cases were identified. Sixty one percent of them were male (n=35), and mean age was 75±11. Fifty two patients had known oncologic disease at the onset of stroke. Most of them had solid tumors (91%, n=52), and 54% (n=31) of patients had a non-metastatic tumor at the time of stroke. Prevalence of common VRF between groups was not significantly different. Previous deep venous thrombosis and pulmonary thromboembolism were more frequent in the cancer cohort (8% vs 1%, p=0.01). The average NIHSS was 3.8±4 in the cancer group and 9±7 in the control group (p=0.01). Small artery disease as the etiology of stroke was significantly less common in the cancer group (2% vs 26%, p=0.001). Regarding neuroimaging, the embolic pattern was more frequent in patients with cancer (82% vs 35%, p=0.001). Mortality at 90 days was six times higher in patients with cancer (18 % vs 3 %, p= 0.001).