To present the data on tPA and its outcome in acute stroke and the difficulties in its usage in low economic countries like in Nepal.

Incidence of stroke is in increasing trend in low income countries like Nepal. Administration of tPA has been licensed in Nepal in acute ischemic stroke only recently. We carried out an observational study on institutional basis in regards to i.v. tPA usage in acute ischemic stroke.

Patients from last two years (2015-2017) diagnosed as ‘acute stroke’ were collected from the database in our institute. Administration of tPA was based on international inclusion and exclusion criteria and international dosing protocol. Information like clinical, demographic, National Institute of Health Stroke Scale (NIHSS) etc, were collected. Observational analysis was carried out.

This study provides a review of the evidence for, and implementation of, tPA. It also shows the current scenario of stroke with specific reference to Nepalese health-care system. This statement is also a call for our neurologist society to work for the betterment of neurological condition of poorer nations.