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Abstract Details

Rate of ischemic stroke and intracranial hemorrhage following left ventricular assist device placement: a systematic review
Cerebrovascular Disease and Interventional Neurology
P4 - Poster Session 4 (5:30 PM-6:30 PM)
3-054

We aimed to determine the rate of ischemic stroke and intracranial hemorrhage following LVAD placement from prior reports using a systematic approach.
Neurologic adverse events including ischemic stroke and intracranial hemorrhage are a potential cause of morbidity in patients with left ventricular assist device (LVAD).
We conducted a systematic review search of relevant English-language studies published between 2000 and 2018 that reported the rate of Ischemic and hemorrhagic stroke after Left Ventricular Assist Device (LVAD) placement, as well as follow-up times, by means of electronic databases search, and by hand searches of reference lists of the retrieved studies.

Fifty-six studies fulfilled our inclusion criteria, which reported on a total of 30,917 patients who underwent LVAD placement.

4 studies (1,086 patients) were randomized trials, 10 studies (1,561 patients) were prospective and 42 (28,270 patients) were retrospective observational studies. At the end of follow up, ischemic stroke and intracranial hemorrhage rates were 7% (95% Confidnece interval (CI); 6%-8%) and 5% (95% CI: 4%-6%) respectively in patients post-LVAD.

Notably Ischemic stroke and intracranial hemorrhage are potentially serious and common adverse events following LVAD placement. Further studies to identify risk factors, outcomes associated with IS and ICH in LVAD patients, and primary prevention of stroke post-LVAD placement is warranted.
Authors/Disclosures
Mohammed Alhaidar, MD
PRESENTER 		Dr. Alhaidar has nothing to disclose.
Hamidreza Saber, MD (Detroit Medical Center/Wayne State Univ Sch Medicine) No disclosure on file
Ali Ebrahim, MD (GVMH) Dr. Ebrahim has nothing to disclose.
Kumar Rajamani, MD, FAAN Dr. Rajamani has nothing to disclose.