Abstract Details

Title Diagnostic Utility of Continuous sEMG Monitoring in a Home Setting - Real-world use of the SPEAC® System

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 6-012

Objective

Report the diagnostic value of long-term, continuous, surface electromyography (sEMG) monitoring of patients for spell characterization in home setting.

Background A quality measure in epilepsy is to record the frequency of seizures at each visit. Outside of a clinical setting, seizure frequency is a patient-reported outcome. Objective seizure data would improve patient care and the assessment of future anti-seizure medications (ASM). The SPEAC® System is designed to alarm for Generalized-Tonic Clonic (GTC) seizures, continuously record sEMG data for physicians to review other motor events, and provide an electronic seizure diary.

Design/Methods The system was used in home and/or hospital settings by 20 patients. Automated GTC seizure detection sensitivity and false alarm rates (FAR) were calculated based on patient reported outcomes and physician review of collected data. Patients were able to have alarm thresholds adjusted by their physician.

Results Patients wore the device for a total of 495 days (average 10.2 h/day). Three GTC seizures were detected. Two occurred in a patient that was wearing the device in an EMU and the third occurred in a patient using the system in a home setting. Neither patient was aware of the GTC seizures. Thirteen patients refused a threshold adjustment and were satisfied with a FAR of 0.5/24 h. Seven patients requested that the sensitivity be adjusted; resulting in a FAR of 0.3/24 h. Seventy percent of cases resulted in physicians reporting a change in their understanding of their patient’s seizures. This resulted in a change of ASM for 15 % of patients.

Conclusions

Accurate information about seizure frequency, and type, would improve treatment decisions and patient outcomes. The SPEAC System provides information about motor seizures that was previously unavailable. Having objective information about seizures that occur outside of a clinical setting would improve patient care and would increase the value of trials of ASM.

Authors/Disclosures
Luke Whitmire, PhD (Brain Sentinel) PRESENTER	No disclosure on file
	No disclosure on file
Damon P. Cardenas, PhD (Brain Sentinel)	No disclosure on file
Jose E. Cavazos, MD, PhD (U Texas Health San Antonio)	Dr. Cavazos has received stock or an ownership interest from Brain Sentinel . The institution of Dr. Cavazos has received research support from NIH.

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