Abstract Details

Title Assessing Retinal Cytoarchitecture between Temporal Onset Focal and Primary Generalized Seizure Types Utilizing Optical Coherence Tomography

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 6-022

Objective To investigate the outcomes of focal onset seizures (FOS) and primary generalized seizures (PGE) on retinal cytoarchitecture.

Background The utility of optical coherence tomography (OCT) for patients with epilepsy is minimal, despite the ease and non-invasive nature of the technique. OCT allows for the quantification of retinal layer thicknesses, which may indicate neuronal health and integrity of white matter tracts throughout the brain. We hypothesize that FOS patients will exhibit more retinal thinning in the inferior quadrant of the peripapillary retinal nerve fiber layer (pRNFL) compared to PGE.

Design/Methods Twenty-two patients with focal seizures originating from the temporal lobe (10 men, 12 women, mean age 44.23: range 21-70 years) and fourteen patients with primary generalized seizures (4 men, 10 women, mean age 31.00: range 19-67 years) underwent OCT imaging. Patients with a history of glaucoma or diabetes were excluded from this study. Analysis of variance (ANOVA) was used to explore the differences between FOS and PGE on retinal thicknesses. Age and disease duration were used as covariates.

Results

Within the quadrant analysis of the peripapillary retinal nerve fiber layer (pRNFL), the papillomacular bundle (PMB) came close to, but did not reach significance between the FOS and PGE groups (p=0.055). Furthermore, the two groups revealed no significant differences in the global thickness of the pRNFL and the total macular volume, (p=0.78) and (p=0.20), respectively.

Conclusions Our data suggests non-significant microanatomical changes within the retinal cytoarchitecture of epilepsy patients with focal and generalized seizure types. However, as we observed a lower PMB for the FOS group, this could be explained by retrograde axonal atrophy. As the optic nerve axons travel through the temporal lobe, where seizures develop in this group, this physiology could translate to the axons within, and thus, the retina. Further studies with imaging are needed to correlate these findings.

Authors/Disclosures
Samuel Lichtman-Mikol, BA (Wayne State University) PRESENTER	Mr. Lichtman-Mikol has nothing to disclose.
Melody Gilroy, BS	Ms. Gilroy has nothing to disclose.
Rachel Darling	No disclosure on file
Kalyan Yarraguntla, MD (University Health Center)	Dr. Yarraguntla has nothing to disclose.
Rohit A. Marawar, MD, FAAN (Wayne State University - Detroit Medical Center)	Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz Pharmaceuticals. Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for SK Pharma. Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Xenon. Dr. Marawar has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Neurelis.
Deepti Zutshi, MD, FAAN (Wayne State University School of Medicine)	Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Xenon pharmaceuticals. An immediate family member of Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aucta Pharmaceuticals. Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aucta.

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