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Abstract Details

Prognosis and Clinical Factors to Predict Seizure Recurrence in Patients with Alcohol-Related Seizures
Epilepsy/Clinical Neurophysiology (EEG)
P4 - Poster Session 4 (5:30 PM-6:30 PM)
6-026
We tried to evaluate the prognosis of seizure recurrence in patients with alcohol-related seizures. Also, we want to demonstrate the prognostic factors of seizure recurrence and development of epilepsy in patients with alcohol-related seizures.

According to the definition of epilepsy, alcohol-withdrawal seizures are defined not belonging to epilepsy. However, seizures can often recur in patients with alcohol-related seizures, and there have been previous literatures to address epileptogenesis related to chronic alcohol consumption. This study aimed to investigate clinical characteristics and prognosis of developing epilepsy in patients with alcohol-related seizures.

Patients were recruited based on the database who had a history of chronic alcohol consumption and hospitalized due to alcohol-related seizures at Ewha University Hospital, 2007~2017. They all received electroencephalogram and brain imaging studies. We enrolled 96 patients and collected clinical data.

We analyzed the comparison of characteristics in 96 patients with or without seizure recurrence. There are significant relationships between EEG findings and seizure recurrence(P value 0.009); between alcohol consumption and seizure recurrence(P value 0.029).

We studied the comparison of characteristics in patients with or without developing epilepsy. There are significant associations between EEG findings and epilepsy(P value  0.073); between seizure recurrence and epilepsy(P value<0.001).

We made a predictive model for developing epilepsy. Seizure recurrence and abnormal EEG are correlated with developing epilepsy in univariate and multivariate analysis. In the multivariate model, odds ratio of seizure recurrence is 3.642, and odds ratio of abnormal EEG is 68.341. This model exhibited the best performance with highest area under the curve of 0.987.

As amount of alcohol consumption increased, the prevalence of seizure recurrence increases. If patients with alcohol-related seizures show abnormal EEG findings, they have higher risk of seizure recurrence and diagnosis of epilepsy. Thus, this study indicates that alcohol consumption can lead to epilepsy, demonstrated by abnormal EEG findings.

Authors/Disclosures
Min Young Chun, MD (Ewha Womans University Mokdong Hospital)
PRESENTER
Dr. Chun has nothing to disclose.
Hyeon Jin Kim, MD (Ewha Women's University, Neurology) No disclosure on file
Eunjin Kwon, MD (Department of Neurology, CHUNGNAM NATIONAL UNIVERSITY HOSPITAL) No disclosure on file
No disclosure on file
Chan Young Lee, MD (Ewha Womans University Mokdong Hospital) No disclosure on file
No disclosure on file
No disclosure on file
Hyang Woon Lee No disclosure on file