Abstract Details

Title Vision loss in Parkinson’s disease: prevalence and association with outcomes among Medicare beneficiaries

Topic General Neurology

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-012

Objective To determine the prevalence of vision loss in older adults with PD and its associations with hip fracture, depression, anxiety, and dementia.

Background Vision loss is a preventable risk factor for injurious falls and neuropsychiatric disorders in the geriatric population. Individuals with Parkinson’s disease (PD) may be at increased risk for vision loss and its undesired consequences.

Design/Methods We performed a retrospective cohort study of Medicare beneficiaries with complete data for the year 2014. PD cases were identified from inpatient and outpatient claims using ICD-9 codes. Diagnoses of low vision, hip fracture, depression, anxiety, and dementia and their dates of incidence were extracted using ICD-9 and procedure code-based algorithms. The prevalence of low vision was compared among PD cases by demographic characteristics using chi-squared tests. Logistic regression models were built to measure the associations between low vision and study outcomes among PD patients, adjusting for demographic characteristics and comorbid diseases.

Results Among 773,905 adults with PD meeting study criteria, the overall prevalence of low vision was 4.05% compared to 0.6% for the non-PD population and varied significantly by demographic characteristics. The prevalence of low vision was especially high for individuals identified as Hispanic (12.9%, AOR 3.97, 3.80-4.15) Native North American (6.8%, AOR 1.85, 1.60-2.16) and Black (7.4%, AOR 2.14, 2.06-2.22), as compared to White (3.6%, AOR 1.00), and also greater among women (4.8%, AOR 1.74, 1.43-1.50) as compared to men (3.3%, AOR 1.00). Low vision was associated with greater odds of incident hip fracture (AOR 1.13, 95% CI: 1.04-1.22, adjusting for demographics, history of dementia) and incident anxiety (AOR 1.11, 95% CI: 1.05-1.18, adjusting for demographics, history of bipolar disorders, depression, dementia) but not incident depression or dementia.

Conclusions Low vision is more common in Medicare beneficiaries with PD and is associated with outcomes commonly attributed to PD severity.

Authors/Disclosures
Ali G. Hamedani, MD, MHS (Hospital of the University of Pennsylvania) PRESENTER	Dr. Hamedani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ArgenX. Dr. Hamedani has received personal compensation in the range of $0-$499 for serving as a Consultant for LoQus23. The institution of Dr. Hamedani has received research support from NIH. The institution of Dr. Hamedani has received research support from Biogen. The institution of Dr. Hamedani has received research support from Biohaven.
Allison Wright Willis, MD (University of Pennsylvania)	Dr. Wright Willis has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Pharmacoepidemiology and Drug Safety. Dr. Wright Willis has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Wright Willis has received research support from NIH. The institution of Dr. Wright Willis has received research support from NIA. The institution of Dr. Wright Willis has received research support from Biogen. The institution of Dr. Wright Willis has received research support from Parkinson Foundation. The institution of Dr. Wright Willis has received research support from Arcadia.

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