Abstract Details

Title Cognitive decline after a mild or moderate stroke and TIA: evidence from the SWIFT Trial

Topic General Neurology

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-015

Objective We describe the short and long-term changes in cognitive status in a sample of mild/moderate stoke/TIA survivors overall and by race-ethnicity.

Background Cognitive status may play a critical role in successful rehabilitation post-stroke.

Design/Methods This analysis uses data from SWIFT, a RCT testing a stroke preparedness intervention. Exclusion included history of dementia or inability to provide consent. A sub-component of SWIFT measured cognitive status using the Telephone Interview for Cognitive Status (TICS), a standardized test validated for use in English and Spanish. Changes in TICS scores were dichotomized to assess cognitive decline at available time points overall, by race-ethnicity, and by age.

Results We administered TICS to 242 of 1193 participants at baseline, 373 at one-month, and 378 at one year. Subgroup baseline demographics: 50% men; 26.5% white, 19.8% black, 47.5% Hispanic; mean age 61.4 (sd = 15.3); mean NIHSS 2.6 (sd=2.8; range 0-14). Mean TICS scores were 31.4 at baseline (sd=6.8), 32.4 at one month (sd=6.4), and 32.1 at one year (sd=7.0). Between baseline and one month 30.5% of participants declined overall, 24.4% of whites, 35.7% of blacks, and 32.7% of Hispanics; mean age of those in decline was 58.1 (sd=15.1) versus 61.0 (sd=15.8). Between one year and baseline 37.6% of participants declined overall, 28.6% of whites, 44.4% of blacks, 40.8% of Hispanics; mean age of those in decline was 60.6 (sd=14.8) versus 58.3 (sd=15.7). Between one year and one month 43.1% of participants declined overall, 45.5% of whites, 38.7% of blacks, 42.3% of Hispanics; mean age of those in decline was 60.9 (sd=12.7) versus 57.7 (sd=16.2). Twenty one percent of those in decline between one month and baseline had a subsequent stroke or TIA compared to 13% of those not in decline.

Conclusions Further research is needed to understand disparities in cognitive decline among stroke survivors.

Authors/Disclosures
Bernadette Boden-Albala, DrPH (University California Irvine) PRESENTER	Ms. Boden-Albala has received research support from NIH.
	No disclosure on file
	No disclosure on file

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