Abstract Details

Title Migraine and the Prevalence of Metabolic Syndrome among Women

Topic General Neurology

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-027

Objective

To evaluate the association between migraine, including migraine subtypes, and prevalent metabolic syndrome among adult women.

Background Although migraine has been associated with individual cardiovascular disease risk factors including hypertension and dyslipidemia, few studies have explored the association between migraine and dysregulation of these risk factors as captured by metabolic syndrome.

Design/Methods

We examined the cross-sectional association between migraine and metabolic syndrome among 28,036 women enrolled in the Women’s Health Study. Women were classified as either having active migraine (including migraine with aura and without aura), past history of migraine, or no history of migraine. Metabolic syndrome was defined as three or more of the following characteristics at baseline: body mass index>26.7 kg/m2, HbA1c≥5.7 or physician diagnosis of diabetes, high-density lipoprotein cholesterol<50 mg/dL, hypertension (either blood pressure≥130/85 mmHg, physician diagnosis of hypertension, or use of blood pressure lowering medications), or triglycerides≥150 mg/dL. Logistic regression models were used to examine the association between migraine and prevalent metabolic syndrome.

Results At baseline, 3638 women reported active migraine (1441 with aura and 2197 without aura) and 1529 reported a past history of migraine; 6887 women had prevalent metabolic syndrome. After multivariable adjustment, women with a past history of migraine had 1.22 times the odds of having metabolic syndrome compared to those with no history of migraine (95% CI: 1.08, 1.37). Women who experience active migraine had a non-significant increased odds of metabolic syndrome (OR=1.06; 95% CI: 0.98, 1.16). This association was primarily driven by women who experience active migraine without aura (OR=1.10; 95% CI: 0.99, 1.22). We observed no association between active migraine with aura and metabolic syndrome (OR=1.01; 95% CI: 0.89, 1.15).

Conclusions The association between migraine and metabolic syndrome is limited to those with a past history of migraine and is not observed among those experiencing active migraine with aura.

Authors/Disclosures
Pamela Rist, PhD (Brigham & Women's Hospital) PRESENTER	The institution of Dr. Rist has received research support from National Institutes of Health. The institution of Dr. Rist has received research support from Brigham and Women's Hospital. The institution of Dr. Rist has received research support from American Heart Association. The institution of Dr. Rist has received research support from Mars Edge.
	No disclosure on file
Daniel Chasman, PhD (Division of Preventive Medicine)	Daniel Chasman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Takeda. Daniel Chasman has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amgen. Daniel Chasman has received research support from Pfizer. Daniel Chasman has received intellectual property interests from a discovery or technology relating to health care.
Tobias Kurth, MD, ScD, FAAN (Charité - Universitätsmedizin Berlin)	Dr. Kurth has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for TotalEnergies. Dr. Kurth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly & Company. Dr. Kurth has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for BMJ. Dr. Kurth has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Frontiers. The institution of Dr. Kurth has received research support from German Joint Committee. The institution of Dr. Kurth has received research support from Ministry of Health.

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