Abstract Details

Title Disability Scores After Idiopathic Pediatric Transverse Myelitis are Associated with Clinical Features at Onset of Illness

Topic Child Neurology and Developmental Neurology

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-040

Objective To identify factors associated with persistent disability and/or conversion to multiple sclerosis (MS) in patients presenting with a first episode of idiopathic transverse myelitis (TM)

Background N/A

Design/Methods A retrospective chart review identified 35 patients diagnosed with TM at age ≤18 years who met inclusion criteria. Data was collected and analyzed for associations with Expanded Disability Status Scores (EDSS) collected on average 2.9 months after onset, and for associations with conversion to MS over an average total follow-up time of 2.6 years.

Results

* 3/35 patients converted to MS over the mean follow-up period of 2.6 years.

* No significant associations were found between conversion to MS and age at onset, event severity, oligoclonal bands, elevated IgG index, patchy cord lesions on MRI, or longitudinally extensive TM (LETM).

* EDSS scores at first follow-up visit ranged from 0 to 8.0 (mean = 1.8).

* Shorter time to nadir of symptoms, absence of patchy spinal lesions, presence of LETM, and absence of CSF pleocytosis were all significantly associated with higher EDSS scores at initial follow-up (all p values ≤0.05).

* No significant associations were found between EDSS scores and age at onset, gender, event severity, or presence of cervical cord lesions.

Conclusions Pediatric idiopathic TM patients have a wide range of outcomes, from complete recovery to severe disability, and from isolated events to development of MS. None of the clinical features assessed were significant for conversion to MS, which differs from previous studies’ findings. A larger sample size may be necessary to detect significant differences between MS converters and non-converters. Despite the small sample size, several features were significantly associated with higher disability scores, including history of shorter time to nadir of symptoms, non-patchy spinal lesions on MRI, LETM, and lack of CSF pleocytosis.

Authors/Disclosures
Jordan J. Cole, MD (Children's Hospital Colorado) PRESENTER	The institution of Dr. Cole has received research support from Child Neurology Career Development Program K12 (through NINDS, 5K12NS098482-07). Dr. Cole has received personal compensation in the range of $500-$4,999 for serving as a Invited speaker with American Epilepsy Society.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Soe S. Mar, MD, FAAN (Washington University School of Medicine)	The institution of Dr. Mar has received research support from NIH.

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