Participants in an AxD Outcomes Study completed a group of multidisciplinary evaluations, including the Comprehensive assessment of the PEDI-CAT, administered on an iPad and answered by a proxy (parent/guardian) for subjects <21 years. Four domains were captured: daily activities (activities of daily living), mobility (motor skills), social (interactions with others), and responsibility (independence). AxD scores were compared to normative scores (for age-matched controls, mean 50, standard deviation [SD] 10) and percentile ranges generated by the program. The Gross Motor Function Measure-88 (GMFM-88) captures gross motor skills across 5 dimensions (lying/rolling, sitting, crawling/kneeling, and standing/walking/running/jumping) and was administered during the same visit. GMFM-88 and mobility scaled scores (which are not age-related but provide data across a continuum for those unlikely to attain age-expected development) were compared using the Pearson’s correlation coefficient.

Proxies of 38 AxD patients completed the PEDI-CAT. Mean normative scores were lower than age-matched youth: activities 26.1 (SD 25.6), mobility 5.0 (SD 49.8), social 27.9 (23.9), and responsibility 30.5 (SD 20.6). The percentages of patients scoring <5^th percentile by domain were: activities 65.79%, mobility 76.32%, social 57.89%, and responsibility 57.89%. Post-hoc analyses revealed a significant correlation between PEDI-CAT mobility scaled scores and GMFM-88 (p<0.001).