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Abstract Details

Gait Analysis of GBA Mutation Carriers with Parkinson’s Disease
Movement Disorders
P4 - Poster Session 4 (5:30 PM-6:30 PM)
1-009

To use quantitative motion analysis to measure gait asymmetry in the glucocerebrosidase (GBA) gene mutation and non-mutation carriers with Parkinson’s disease (PD) in the OFF state compared with healthy controls (HCs).

GBA mutation carriers with PD are at higher risk of cognitive decline, but the motor phenotype is not well defined. We hypothesized that GBA mutation carriers had more symmetric arm swing velocity, stride length, and arm swing range of motion (ROM) compared with non-mutation carriers.

We screened 88 PD subjects and identified 11 GBA mutation carriers. Non-mutation carriers and HCs were matched to GBA mutation carriers based on age of onset, disease duration, and sex. GBA mutation carriers and matched non-mutation carriers completed the Instrumented Stand and Walk test and neurologic exam. Asymmetry in arm swing velocity, stride length, and arm swing range of motion were calculated and compared between the 3 groups.

Motion analysis results were available for 16 non-mutation carriers, 11 GBA mutation carriers, and 11 HCs. No significant difference in age of onset, sex, disease duration, or H&Y stage was found comparing the 3 groups. Significant differences were found between GBA-mutation carriers (and non-mutation carriers in measures of arm swing velocity asymmetry (10.9 +/- 8.1 vs. 22.9 +/- 12.2 degrees/sec, respectively p = 0.032) and in arm ROM asymmetry for non-mutation carriers (degrees) vs. HCs (32.3 +/- 18.7 vs. 15.0 +/- 14.1 degrees, respectively, p=0.027).

GBA mutation carriers demonstrate more symmetric arm swing velocity than non-GBA mutation carriers. GBA mutation carriers demonstrate arm swing asymmetry and arm ROM asymmetry that was comparable to that seen in healthy controls. Arm swing velocity asymmetry may be a marker of GBA status.
Authors/Disclosures
Anjali Gera, MD (Northwestern Medicine Central Dupage Hospital)
PRESENTER 		Dr. Gera has nothing to disclose.
No disclosure on file
Bichun Ouyang Bichum Ouyang has nothing to disclose.
Gian D. Pal, MD (Rutgers University) Dr. Pal has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint. Dr. Pal has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Kyowa Kirin. Dr. Pal has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for CLRM Law. Dr. Pal has stock in Baudax Bio. The institution of Dr. Pal has received research support from National Institutes of Health. The institution of Dr. Pal has received research support from Parkinson's Foundation. Dr. Pal has received personal compensation in the range of $500-$4,999 for serving as a Consultant with RKV Firm.