Abstract Details

Title Hand Motor Control in Patients with Cervical Dystonia: an fMRI Study

Topic Movement Disorders

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-008

Objective The aim of this study was to assess the brain activation during voluntary hand movement in patients with cervical dystonia (CD) with respect to the task difficulty and motor performance.

Background Cervical dystonia (CD) is a movement disorder characterized by involuntary muscle contractions leading to abnormal head posture. Despite the predominantly focal manifestation, CD is also associated with discrete deficits in praxis and abnormal sensorimotor activation during sequential finger movements. However, the relationship between the motor task difficulty, apraxia and abnormal fMRI activation remains unclear.

Design/Methods Fifteen patients with CD regularly treated with intramuscular BoNT-A at the Department of Neurology of the University Hospital Olomouc enrolled in this study (10 females, mean age 51.3±9.1, all right-handed). Participants underwent a single fMRI examination using a 3T Siemens Prisma scanner 4 weeks after the last BoNT-A application. In the scanner, participants performed blocks of sequential finger tapping with their right hand according to visually presented cues. One half of the blocks consisted of a repeated constant sequence, whereas the second half consisted of pseudorandom sequences. The statistical fMRI analysis yielded differences in task-related activation between the constant and random conditions.

Results Both conditions were associated with bilateral activation in cortical and cerebellar sensorimotor areas, while motor preparation during cue resulted in higher activation than motor execution. Random condition was associated with increased activation in the premotor and posterior parietal cortex. During motor preparation, this was observed in the left hemisphere, whereas during the motor execution, it was apparent in both hemispheres.

Conclusions The results show different activation patterns during constant and random sequential movement, and an increased activation in the preparatory phase of the movement. In a follow-up, the data will be compared to age- and sex-matched healthy controls.

Authors/Disclosures
Pavel Hok, MD (University Hospital Olomouc) PRESENTER	Dr. Hok has nothing to disclose.
	No disclosure on file
Martin Nevrly, MD (FN Olomouc)	No disclosure on file
Lenka Hvizdosova	No disclosure on file
	No disclosure on file
Petr Kanovsky, PhD	Dr. Kanovsky has nothing to disclose.
Petr Hlustik, MD, PhD (Palacký University Olomouc)	The institution of Prof. Hlustik has received research support from Czech Health Research Council (AZV CR).

��ɫ��

��ɫ��