Abstract Details

Title Self-Reported Substance Use in a Real-World Sample of Subjects with Tourette Syndrome and Other Tic Disorder.

Topic Movement Disorders

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-038

Objective To evaluate the use of illegal substances in a “real world” sample of subjects with a diagnosis of Tourette syndrome (TS) or other tic disorders (TD).

Background TS is a complex neuropsychiatric disorder. Individuals with TS are at an increased risk for substance use disorders.

Design/Methods A web-based survey was conducted by the Tourette Association of America, disseminated electronically to its membership (Jan-May/2018). Participants were informed that data would be used anonymously in aggregate to assess impact and experience of living with TS/TD. Only adult self-responders who completed the substance use question were included in this analysis.

Results 223 out of 281 adults were included in the analysis. 75.3% (n=168) were diagnosed for 10 years or longer and 63.2% (n=141) were diagnosed by a neurologist. 23.3% (n=52) reported ever using any illegal substance. In this group, 71.2% (n=37) used 1 substance, 13.5% (n=7) used 2 substances, 11.5% (n=6) used 3 substances, and 3.8% (n=2) used 5 substances. Alcohol was the most commonly used substance at 59.6% (n=31). Using Chi-square test of independence revealed a significant relationship between substance use and a history of self-harm/suicide X²(1, n=222)=9.58, p=0.002 (phi=0.21), as well as a history of being discriminated against or bullied, X²(1, 220)=5.47, p=0.019 (phi=0.16). Notably there was no significant relation to financial burden, missing work/school, or social impairment. Results of the Spearman correlation indicated that there was a significant positive association between the number of substances used and the number of medications tried, (r_s(211)=0.22, p=0.002).

Conclusions This study reveals a relatively high rate of substance abuse in adults with TS/TD (23.3% compared to 12.8% previously reported). Alcohol is the most commonly abused substance. Substance abuse appears to be weakly related to a history of suicide, being discriminated against, and multiple medication trials. Further studies to evaluate these associations are warranted.

Authors/Disclosures
Wissam G. Deeb, MD (UMass Memorial) PRESENTER	Dr. Deeb has a non-compensated relationship as a Board member with Davis Phinney Foundation that is relevant to AAN interests or activities.
Ahmad El Kouzi, MD, FAAN	Dr. El Kouzi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie.
Irene Malaty, MD, FAAN (University of Florida)	Dr. Malaty has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Malaty has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aevum. The institution of Dr. Malaty has received research support from Abbvie. The institution of Dr. Malaty has received research support from Revance. The institution of Dr. Malaty has received research support from Parkinson Foundation. The institution of Dr. Malaty has received research support from SAGE. The institution of Dr. Malaty has received research support from Emalex. The institution of Dr. Malaty has received research support from Acadia. Dr. Malaty has received publishing royalties from a publication relating to health care. Dr. Malaty has received personal compensation in the range of $500-$4,999 for serving as a Speaker & Center of Excellence Director with Parkinson Foundation. Dr. Malaty has a non-compensated relationship as a MAB member & Center of Excellence Directory with Tourette Association of America that is relevant to AAN interests or activities.

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