Abstract Details

Title Increased Caloric Intake is Associated with Lower Cognitive Scores in HIV-Positive Women

Topic Infectious Disease

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 4-002

Objective

To evaluate the association between caloric intake and cognitive performance in HIV-positive and sociodemographically similar HIV-negative women

Background Women with HIV are particularly vulnerable to cognitive decline. Increased caloric intake has been associated with cognitive decline in the HIV-negative population. We sought to evaluate the effects of caloric intake on our cohort of HIV-positive and HIV-negative women.

Design/Methods Analysis included 166 women (113 HIV-positive and 53 HIV-negative) participating in the Chicago Women’s Interagency HIV Study (WIHS) who completed both cognitive testing and Block 2014 Food Frequency Questionnaire within 18 months. Cognitive t-scores were adjusted for age, education, race, practice effect, and WRAT score, a measure of educational attainment. Linear regression was performed evaluating the effects of log-transformed calories on cognitive domain t-scores

Results The women were majority African American (85%) with median age of 50.7 years (range 32 to 74) and median daily caloric intake of 2084 kcal/day without significant differences by HIV status. HIV-positive women were less likely to have post-high school education (p=0.06) but had similar WRAT scores. Caloric intake was not normally distributed and, therefore, log-transformed. In regression models, increasing calorie intake was significantly associated with lower executive function (p=0.032), psychomotor speed (p=0.002), attention/concentration (p=0.004), verbal learning (p=0.04) and fine motor skills (p=0.007) t-scores. Increased caloric intake had significant negative association with psychomotor speed in both HIV-positive (p=0.03) and HIV-negative women (p=0.007). Among HIV-positive but not HIV-negative women, there were significant negative associations of caloric intake with executive function (p=0.038), attention/concentration (p=0.0006) and fine motor skills (p=0.0004).

Conclusions

We found that higher caloric intake is associated with lower scores in many cognitive domains in our cohort of urban, HIV-positive and negative women. In several domains, associations were seen only in HIV-positive women. Further study, including evaluation of the potential effects of energy expenditure, are needed to better understand this association.

Authors/Disclosures
Lakshmi Warrior, MD, FAAN PRESENTER	Dr. Warrior has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file

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