A 59 year-old-male with history of prior resection and chemoradiation for glioblastoma multiforme (GBM) underwent an uncomplicated right temporal resection for recurrent disease. He subsequently presented with dysarthria, left sided weakness, alteration of consciousness and focal-onset seizures 13 days post-operatively. Diagnostic evaluation identified white blood cell elevation in his cerebrospinal fluid (12/µL; 92% monocytes, 7% lymphocytes), elevated red cell count (40/µL), elevated protein (>600 mg/dL) and detection of HSV-2 via PCR testing; other diagnostic tests, including CSF bacterial cultures, were negative.  His past medical history was significant for previous herpes labialis but not genital herpes. Magnetic resonance imaging of the brain demonstrated restricted diffusion and increased FLAIR signal within right temporal and frontoparietal lobes with associated enhancement. He was treated with acyclovir 10 mg/kg every eight hours, and he required multiple anesthetic agents to control his seizures.  Given his overall prognosis in the setting of recurrent GBM and a prolonged period of recovery expected following super-refractory status epilepticus, his family elected to transition to comfort care two weeks following hospital admission.