Abstract Details

Title Healthcare resource use and humanistic burden associated with attack frequency in episodic cluster headache

Topic Headache

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 13-019

Objective To determine the impact of cluster headache attack frequency on resource use and burden.

Background Patients with episodic Cluster Headache (CH) experience excruciatingly painful unilateral headache attacks up to 8 times/day. The impact of CH attack frequency on patients and the healthcare system is poorly characterized.

Design/Methods Data were drawn from the Adelphi 2017 CH Disease Specific Programme, a cross-sectional survey including physicians from Germany, UK and US and their consulting patients with CH. Physicians reported hospitalizations and patients reported on overall work and activity impairment using the Work Productivity and Activity Impairment questionnaire (WPAI). Health status and quality of life were captured using the EuroQoL 5-Dimensions 5-Levels questionnaire (EQ-5D-5L). Patients with episodic CH were segmented into those experiencing ≤1 (n=388), >1-≤2 (n=175), >2-≤3 (n=112) and >3 (n=201) attacks per day (APD), on average, and were analyzed descriptively.

Results Patients were a mean age of 40.9 years, male (67%), and employed (78%). Hospitalization rates in the last 12 months for CH increased as APD increased (≤1, 7%; >1-≤2, 9%; >2-≤3, 10%; >3, 13%). Among those employed, WPAI results generally demonstrated a greater burden for patients suffering more APD: work impairment (≤1, 19%; >1-≤2, 19%; >2-≤3, 23%; >3, 26%); and inconsistently for overall activity impairment (≤1, 21%; >1-≤2, 17%; >2-≤3, 24%; >3, 28%). These outcomes were exacerbated for patients in an active cluster period. Mean EQ-5D-5L for patients experiencing an active cluster period (n=143) was 0.79, min/max 0.28-1.0, (≤1, 0.80; >1-≤2, 0.73; >2-≤3, 0.83; >3, 0.75) and 67.6 for the visual analog scale (≤1, 65.5; >1-≤2, 69.4; >2-≤3, 67.4; >3, 66.8). Health status was less impaired for patients (n=457) not currently within a cluster period.

Conclusions Episodic CH is marked by considerable overall burden, underlining the need for effective medications that reduce attack frequency. Increased APD were generally, but inconsistently associated with greater burden.

Authors/Disclosures
J S. Andrews PRESENTER	J Scott Andrews has received personal compensation for serving as an employee of Eli Lilly & Company. J Scott Andrews has received stock or an ownership interest from Eli Lilly & Company.
Antje Tockhorn-Heidenreich	Antje Tockhorn-Heidenreich has received personal compensation for serving as an employee of Eli Lilly and Company. An immediate family member of Antje Tockhorn-Heidenreich has received personal compensation for serving as an employee of Evidera. Antje Tockhorn-Heidenreich has received stock or an ownership interest from Eli Lilly and Company . An immediate family member of Antje Tockhorn-Heidenreich has received stock or an ownership interest from PPD.
James Jackson (Adelphi Real World)	James Jackson has nothing to disclose.
Russell Nichols	Russell Nichols has received personal compensation for serving as an employee of Eli Lilly and Company. Russell Nichols has received stock or an ownership interest from Eli Lilly and Company.
Sarah Cotton	Sarah Cotton has nothing to disclose.
	No disclosure on file
	No disclosure on file
James Martinez	No disclosure on file

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