好色先生

好色先生

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Abstract Details

Associations Between Amyloid Burden, White Matter Hyperintensities and Cognition in Cognitively Normal Older Adults
Aging, Dementia, and Behavioral Neurology
P5 - Poster Session 5 (5:30 PM-6:30 PM)
9-016

To model the contributions of white matter hyperintensities(WMH) and amyloid burden to cognitive ability in the domains of executive function, attention and verbal memory in clinically unimpaired older adults.

Beta amyloid deposition and WMH are known biomarkers of neurodegeneration in aging. While their accumulation has clear correlations with cognition in impaired populations, their significance is debated in cognitively normal older adults.
103 older adults without clinical cognitive impairment were included. Mean age was 71(SD 5), mean years of education were 17(SD 3) and 74% were female. Amyloid burden was assessed using Florbetapir(18F) PET. WMH were measured as lesion volume from MRI imaging using Lesion Segmentation Tool. Cognitive domains of verbal memory, attention and executive function were derived from a neuropsychological battery using factor analysis which was confirmed without reference to biomarkers. Path analysis compared relationships between these cognitive factors, amyloid and white matter disease as well as age, sex and education.
The path analysis demonstrated good fit. WMH did not approach a significant association with any cognitive domain. Amyloid was negatively associated with memory and executive function in a model excluding age. These associations were near but above our threshold for significance in our full model which included age. Age was negatively associated with performance in all cognitive domains. 好色先生 was positively associated with attention, and female gender predicted better performance in executive function and memory.
Our study supports age as a stronger predictor of cognition than amyloid burden or white matter disease in clinically unimpaired older adults. The lack of significant associations seen with WMH suggests a negligible effect on our measures of cognition at the low volumes seen in our unimpaired sample. Amyloid burden may show small but significant associations with verbal memory and executive function independent of age in a larger sample.
Authors/Disclosures
Benjamin Chapin, MD (UF)
PRESENTER 		Dr. Chapin has nothing to disclose.
Eric Vidoni, PhD, PT (ALZHEIMER & MEMORY PROGRAM) No disclosure on file
No disclosure on file
Jeffrey M. Burns, MD (University of Kansas) Dr. Burns has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Renew Research. Dr. Burns has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Burns has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx. Dr. Burns has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Norris, Keplinger, Hicks and Welder. The institution of Dr. Burns has received research support from National Institutes of Health. The institution of Dr. Burns has received research support from Biogen. The institution of Dr. Burns has received research support from Eli Lilly. The institution of Dr. Burns has received research support from Amylyx. The institution of Dr. Burns has received research support from Abbvie. The institution of Dr. Burns has received research support from Astra-Zeneca.