Abstract Details

Title Structural Brain Organization Associated with Gait in Mild Cognitive Impairment Subtypes

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 9-032

Objective This study aims to characterize the structural covariance networks associated with gait speed in patients with amnestic mild cognitive impairment (a-MCI) and non-amnestic MCI (na-MCI).

Background Gait is affected in the early stages of dementia, like mild cognitive impairment (MCI). Structural covariance analysis – a method measuring the topographical brain organization - allows to map the pattern of covariance between the grey matter (GM) regions that subserve a particular motor or cognitive function, such as gait.

Design/Methods

Gait speed was measured in 41 patients with a-MCI and 130 na-MCI (age 72.0 ± 5.1; 36.8 % female) at comfortable and fast speed. Structural covariance networks have been computed using voxel-based morphometry with the main neural correlates of gait speed in each group and for each walking conditions as seed regions.

Results Normal gait speed was correlated with GM volume in the left frontal cortex in patients with a-MCI and in bilateral caudate and left putamen in na-MCI. Fast gait speed was correlated with GM volume in bilateral caudate and right cerebellum in na-MCI, but no correlation was found in a-MCI. The structural covariance analysis for normal gait speed revealed that the left caudate nucleus in na-MCI was structurally associated with a subcortico-frontal network, while the left frontal cortex was associated with a cortical network involving the frontal cortex in a-MCI. For fast speed, a similar subcortico-frontal network than for normal speed was revealed in na-MCI.

Conclusions The key neural correlates of gait speed and their associated structural brain networks vary according to the type of MCI, with a subcortico-frontal network in na-MCI and a “pure” cortical network involving the frontal cortex in a-MCI. This analysis demonstrated various underlying brain changes associated with gait modifications in older adults at early stage of dementia.

Authors/Disclosures
Gilles Allali, MD, PhD PRESENTER	Dr. Allali has nothing to disclose.
Maxime Montembeault, PhD (UCSF Memory and Aging Center)	Dr. Montembeault has nothing to disclose.
	No disclosure on file

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