Abstract Details

Title Investigation into the Relationship between Digital Brain Volume and Computerized Screening Assessment of Cognitive Function in People with Multiple Sclerosis: Objective Analytics to Quantify Disease Impact – Cross Sectional Relationship

Topic Multiple Sclerosis

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-031

Objective To examine the relationship between digitized brain volume and computerized multi-domain cognitive screening battery in people with MS.

Background

Multiple Sclerosis (MS) impact/progression is traditionally quantified by subjective and objective data including: patient reported outcomes (PRO), reported relapse rate, EDSS and visualized MRI changes. Use of traditional metrics might be insufficient to provide multidimensional information that is patient centric along a continuum of disability to measure critical milestones of change by current monitoring approaches. Incorporation of both a computerized multidimensional cognitive screening battery (CAB) and analysis of MRI identification of disease impact might provide important information that can impact treatment. The cross-sectional relationship of CAB to digital analysis of brain volume in PwMS has not been established.

Design/Methods Retrospective review of PwMS who underwent both a validated multi-domain computerized cognitive screening battery (CAB-NeuroTrax) and MRI digital measurements (Icometrix) of whole brain volume (WBV) and FLAIR white matter (WM) hyper-intensity volume in routine care. CAB-Neurotrax analysis included: memory (Mem), executive function (Exe), attention (Attn), visual spatial (Vis-Spat), verbal function (Ver), and information processing (Inf-Pro), Global Cognitive Summary Score (GCS), as well as the number of Cognitive Domains Impaired #CDI) >1 standard deviation from age/education controls. Linear regression analysis was used to test the significance, which was set at p<0.05.

Results 127 PwMS, 72.8% female, average age 51.18 +/- 10.6. Significant relationships were identified: WBV and GCS (p=0.0025), Mem (p=0.0087), Exe (p=0.0107), Verb (p=0.0003), and #CDI (p=0.0059). FLAIR WM Hyper-intensity Volume and GCS (p=0.0034), Mem (p=0.0546), Exe (p=0.0404), Vis-Spat (p=0.0454), Ver (p=0.0045), Inf-Pro (0.0215), and #CDI (p=0.0092).

Conclusions In PwMS digital measures of brain volume are related to computerized screening assessment of multiple cognitive domains. This quantified objective analytic approach adds examiner independent information about disease impact in a way that can supplement/improve the sensitivity of current approaches to evaluation of disease impact/progression.

Authors/Disclosures
Jared Srinivasan PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Myassar Zarif	Myassar Zarif has nothing to disclose.
Barbara Bumstead, NP	Ms. Bumstead has nothing to disclose.
Marijean Buhse (Stony Brook University)	Marijean Buhse has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen.
Cynthia L. Sullivan, PhD (Neuropsychology Associates of Fairfax)	No disclosure on file
Jeffrey A. Wilken, PhD (NAF)	No disclosure on file
Daniel Golan, MD (Carmel Medical Center)	No disclosure on file
Mark Gudesblatt, MD (South Shore Neurology Assoc. PC)	The institution of Dr. Gudesblatt has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for genentech. The institution of Dr. Gudesblatt has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen.

��ɫ��

��ɫ��