Abstract Details

Title Cortical Thickness, Subcortical Volumes and Disability in Multiple Sclerosis: A Prospective Longitudinal Study

Topic Multiple Sclerosis

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-049

Objective To assess the correlation between cortical thickness, deep grey matter structures (DGM) and disability in relapsing remitting multiple sclerosis(RRMS) patients over forty-eight months.

Background The association between cortical thickness and subcortical DGM volumes with disability have been inconsistent in previous studies, mainly due to a heterogenous MS population being on various disease modifying therapies and non-standardized imaging protocols. Cortical thickness along with DGM atrophy and its longitudinal correlation with disability in a homogenously treated population has been evaluated in very few studies.

Design/Methods Fifty patients(32F/18M) with RRMS from a prospective, open-label clinical trial, on fingolimod were assessed at baseline and year 2. Mean age was 40.8(22-60) years, mean disease duration 8.5(2-26) years and mean expanded disability status scale (EDSS) was 3.2(0- 6.5). Cortical thickness and DGM volumes were calculated from 3D MPRAGE sequence using Freesurfer image analysis version 5. Pearson’s partial correlation, corrected for age and disease duration was used for data analysis (IBM SPSS, v25).

Results Global cortical thickness showed a significant improving inverse correlation with EDSS at study entry(r=-0.406;p=0.007) and 24 months(r=-0.531;p<0.0001). At year 2, temporal lobes showed the strongest inverse correlation with EDSS (r=-0.547;p<0.0001), followed by parietal lobes (r=-0.497; p=0.001). Compared to study entry (temporal, r=-0.387;p=0.01; parietal, r=-0.402,p=0.008), both these had a stronger correlation at 24 months. Cingulate lobes did not indicate a correlation with disability at baseline (p=0.127), however it reached significance at year 2 (r=-0.484;p=0.001). DGM analysis showed a robust inverse correlation for nucleus accumbens (r=-0.595;p<0.0001) at year two. Putamen(r=-0.543;p<0.0001) and globus pallidi(r=-0.456;p=0.002) showed a stronger correlation with EDSS at year two compared to baseline.

Conclusions Our results suggest a significant association between cortical thickness and disability, particularly in temporal, parietal and cingulate lobes. DGM nuclei volumes, especially accumbens and putamen correlated with disability as well. The above structures may be used as potential biomarkers of disability in RRMS.

Authors/Disclosures
Mihir Kakara, MD PRESENTER	Dr. Kakara has nothing to disclose.
Sara Razmjou-Schwarz, MD (Mclaren Macomb hospital)	No disclosure on file
David Chaar, MD	Dr. Chaar has nothing to disclose.
Kalyan Yarraguntla, MD (University Health Center)	Dr. Yarraguntla has nothing to disclose.
Fen Bao	Fen Bao has nothing to disclose.
Carla E. Santiago-Martinez (Wayne State University)	Ms. Santiago-Martinez has nothing to disclose.
Evanthia Bernitsas, MD, FAAN (Wayne State School of Medicine)	Dr. Bernitsas has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Bernitsas has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Vanda. The institution of Dr. Bernitsas has received research support from Roche/Genentech.

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