Abstract Details

Title Cognitive-motor interaction in Multiple Sclerosis: how it impacts on patient’s Quality of Life.

Topic Multiple Sclerosis

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-104

Objective

1) To compare cognitive-motor interaction (CMI) between MS patients and healthy controls. 2) To examine the relationship between CMI and health-related quality of life (HRQoL).

Background

Multiple sclerosis (MS) patients present cognitive and motor deficits. They are usually evaluated separately, however, recent studies have found interaction when these tasks are performed simultaneously (Cognitive-Motor Interaction, CMI). The research in CMI allows a more ecological approach to the description of the pathology.

Design/Methods Seventy one patients with relapsing remitting MS and 20 healthy controls were included. Age: 39.0 ± 11.14, 34.00 ± 14.25; ��ɫ��: 13.48 ± 3.51, 14.75 ± 2.17 respectively; EDSS: 2.20 ± 1.34; Years of evolution: 9.53 ± 8.40. Outcome measures: Clinical variables: EDSS; Fatigue Severity Scale; Beck’s Depression Inventory II. HRQoL: MS International QoL Questionnarie (MusiQoL); Cognitive variables: BICAMS Battery; Dual tasks: Two cognitive-motor interaction tasks (walking while performing verbal fluency/counting). The measure of the difference between subject performance in the simple task and in the dual task situation was obtained. It was quantified: time, number of steps and cognitive performance. Parametric and nonparametric statistics were performed, to define significance a p value <0.05 was accepted.

Results

Patients and controls were similar in age and education (p = 0.268, p = 0.083). Significant differences were found between patients and controls in CMI, in time and steps of the counting task (p = 0.023, p = 0.005), and in the performance of both cognitive tasks (fluency p = 0.028, counting p < 0.001). Significant negative correlations were found between CMI and dimensions of HRQoL (rS = - 0.299 to -0.558). CMI constituted as a predictor of performance in HRQoL (R²= 0.380, p= 0.007).

Conclusions

Conclusions: MS patients show alterations in CMI. This performance has a significant impact in HRQoL that should be considered in patient’s treatment.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Ricardo Alonso	Ricardo Alonso has nothing to disclose.
Berenice Silva	SIlva Berenice has nothing to disclose.
Sandra Vanotti, MD (Biogen Idec)	No disclosure on file
Domingo O. Garcea, MD	No disclosure on file

��ɫ����

��ɫ����

��ɫ��

��ɫ��