The DAWN trial used a target of <140mmHg and there is retrospective evidence that a target of <160mmHg is associated with good outcomes.  Herein, we report a retrospective study of likelihood of good outcomes based on relative SBP control after successful ET. 

ROC analysis found that when 45% of SBP readings exceeded 140mmHg, there was a poor outcome at 90 days with sensitivity and specificity of 61 and 82%, respectively.  The AUC of this analysis was 0.71 with a p-value of <0.05. The PPV and NPV for this cutoff were 80% and 66%, respectively.

The percentage of time that SBP exceeds the target of 140mmHg in the first 24 hours appears to have an independent correlation with outcome in patients after successful ET.  Those patients with uncontrolled SBP, defined as SBP >140mmHg 45% of the time or more experienced a poor outcome in 80% of cases.  Those patients with controlled SBP, defined as <140mmHg 55% of the time or more experienced a good outcome in 82% of cases.  Our study has limitations due to the retrospective nature and small sample size.  While the values we studied for SBP control do not represent the continuously variable nature of this parameter, they do represent a general trend and are compatible with the standard of care seen amongst facilities providing ET.