Abstract Details

Title Life Expectancy in Familial Cerebral Cavernous Malformation: An Analysis of Prospective Database

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-019

Objective The objective of study is to find out the average life expectancy in patients with familial cerebral cavernous malformation (CCM) patients and to evaluate the cause of death.

Background

The familial CCM has been estimated to be 0.5-1.0% prevalent in the general population with a highest prevalence in Hispanic population. CCM1 is the most common genetic mutation, predominant in southwest United States. The symptomatic intracerebral hemorrhage is the most feared complication of familial CCM. The average life span of Hispanics in United States is 80.6.

Design/Methods A retrospective analysis of patients with familial CCM from University of New Mexico Hospital (UNMH) CCM registry during 2009-2018. Clinical follow up was done on patients every three years. All patients who died during this registry period were included. Data was collected from the database, including their demographics, baseline medical history, comorbid conditions, primary cause of death and age at the time of death.

Results A total of 364 patients were included in the study. Among these, 6 patients died from the beginning of registry till to date. The average age at the time of death was 55.5 years (range: 39 – 67 years). All of these deaths were unrelated to hemorrhage secondary to familial CCM. The primary causes of death was found to be myocardial infarction in 2 patients, sepsis in 1, ischemic stroke in 1, and pleural effusion in 1 patient. One death was related to respiratory failure secondary to withdrawal of ventilator support per family’s wishes. The common comorbidities in these patients were hypertension, Hyperlipidemia, pulmonary thromboembolism, and seizure disorders.

Conclusions

Our study shows the average life expectancy of 55.5 years in patients with familial CCM is significantly lower than average life expectancy of Hispanics in US. All deaths were unrelated to cavernous malformation or its complications including hemorrhage; instead, were related to other comorbidities.

Authors/Disclosures
Nazeem Arsalan, MD (University of New Mexico, Neurology Dept.) PRESENTER	No disclosure on file
Sajid Suriya, MD	Dr. Suriya has nothing to disclose.
Mudassir Farooqui, MD	Dr. Farooqui has nothing to disclose.
	No disclosure on file
	No disclosure on file
Asad Ikram, MD, MBBS	Dr. Ikram has nothing to disclose.
Leslie A. Morrison, MD, FAAN (Dept of Neurology)	No disclosure on file
Atif Zafar, MD (St. Michael's Hospital (University of Toronto))	Dr. Zafar has nothing to disclose.

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