Abstract Details

Title Subclinical peripheral arterial disease in patients with acute ischemic stroke; study with an ultrasonography

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-061

Objective To investigate the clinical implication of PAD confirmed by lower extremity ultrasonography (LEUS) with consideration of its location.

Background Peripheral arterial disease (PAD) is an advanced form of atherosclerosis. The presence of PAD affects the clinical outcome of ischemic stroke, which was defined by abnormal ankle brachial index (ABI). However ABI has no information of the location of atherosclerosis.

Design/Methods Acute ischemic stroke patients who admitted to our stroke center received LEUS during admission and were enrolled. Patients with and without atherosclerosis observed from the LEUS was categorized to PAD+ and PAD- patients, respectively. PAD+ patients were further divided to those with PAD at the proximal part (femoral artery; PADP) and at the distal part (popliteal artery; PADD). The clinical outcome was compared between PAD+ and PAD- patients, and between PADP and PADD. The location of atherosclerosis at cerebral artery was also compared between each group.

Results Among 289 patients enrolled, PAD was observed from 108 (37.4%) patients. PAD+ patients were slightly older (72.2±9.7 vs 65.7±11.6, p<0.001) and had more significant carotid artery stenosis (32.4% vs 12.7%, p <0.001). There was no difference in terms of vascular risk factors or stroke subtypes. Patients with PAD+ had poor 3-month functional outcome (modified Rankin Scale: 2.5±1.8 vs 2.0±1.6, p=0.031). Significant carotid artery stenosis was more prevalent in those with PADP than PADD (44.2% vs 24.6%, p =0.033, respectively). However, the functional outcome did not differ between those with PADP and PADD.

Conclusions Our study suggested that subclinical PAD associated with poor functional outcome at 3 months after stroke onset. The presence of PAD, especially PADP was associated with the presence of significant stenosis at the carotid artery.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Bum Joon Kim (Kyung Hee University)	Dr. Kim has nothing to disclose.

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