Abstract Details

Title Assessment of disease severity in patients with Myasthenia Gravis – Clinical Phenotype and Immunological Correlation

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 12-029

Objective To study the clinical, laboratory and electrophysiological profile in patients diagnosed with Myasthenia Gravis and correlation between disease severity and AChR antibody titres

Background

Myasthenia Gravis is a potentially serious but treatable disorder affecting neuromuscular junction. MGFA, QMG and Myaesthenia gravis composite scores can be used for severity assessment and outcome. Disease severity correlation with AChR antibody titres was not well studied in Indian population.

Design/Methods A cross-sectional study was conducted from April, 2017 to May, 2018 on 32 patients diagnosed with Myasthenia Gravis in Department of Neurology, King George Hospital, Visakhapatnam, India. Disease severity assessment was made with MGFA, QMG and Composite Scores. All patients underwent AChR antibodies and CT chest. Correlation between disease severity and AChR Ab titres was assessed by SPSS software.

Results In this study, 62% were female and the mean age of onset was 38 years. 26 (81.2%) patients belong to EOMG and 6 patients belong to LOMG. Onset was ocular in 81.3%, limb girdle in 12.5%, generalized in 3.1%, bulbar in 3.1%. MGFA I (21.9%), IIA (15.6%), II B(12.5%), IIIA(34.4%), IIIB (9.4%), IVA (3.1%), IVB (3.1%). QMG score showed a strong correlation with MGC score in assessing disease severity (r-0.83, p-<0.001). RNS test showed decremental response at 3Hz in 96% of patients. CT chest revealed thymic hyperplasia in 2 patients, thymoma in 3 patients. AChR Antibodies (Mean titre- 8.34) were positive in 14.3% of Ocular MG and 59% of patients with Generalized MG patients. QMG score and MGC score showed a moderate correlation with AChR Ab titres (r-0.40, p-0.001 and r-0.49, p-0.001 respectively).

Conclusions

QMG score for disease severity is positively associated with MGC score. QMG score and MGC score demonstrated a good correlation with AChR Ab titres. Thus, AChR Ab titres can serve as a tool for assessing disease severity.

Authors/Disclosures
Butchi Raju Garuda, MD, FAAN (Andhra Medical Cillege) PRESENTER	Dr. Garuda has nothing to disclose.
Deepthi Vemuri	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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