Abstract Details

Title Analysis of Patient Characteristics and Outcomes by Prior AED use: Data from Pooled Observational Studies of Routine Perampanel use across Europe

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 6-016

Objective To explore the impact of number of previously used antiepileptic drugs (AEDs) on retention on treatment, seizure freedom, and adverse events with perampanel in clinical practice.

Background Primary outcomes from this cohort have been published previously (Rohracher et al. Epilepsia 2018;59:1727–39). This post-hoc analysis has not been published or presented before.

Design/Methods Pooled analysis using individual patient data from retrospective, observational studies of perampanel initiated between June 2009 and July 2016 in 45 clinics in Spain, Italy, Germany, the UK, France, Austria and Sweden. Patients with available data were grouped by number of previous AEDs used before perampanel initiation. Demographics are described for each group. Retention, 1-year seizure freedom, and adverse events were compared using rates and 95% confidence intervals (CIs).

Results Data from 2396 patients were evaluated, and 2229 patients were included. In those with 0–1 (N=135); 2–3 (N=333) and ≥4 previous AEDs (N=1761), age, gender, duration of epilepsy, age at perampanel initiation, seizure etiology, number of concomitant AEDs, use of enzyme-inducing AEDs, and duration of time on perampanel were broadly similar across the groups. Mean perampanel doses were 6, 7, and 8 mg/day (median [interquartile range]: 6 [4–8]; 8 [6–8]; and 8 mg [6–10]). 1-year retention rates were similar, and CIs overlapped, in those with 0–1 (57.5% [95% CI 49–66], 77/134); 2–3 (50.3% [45–56], 162/322), and ≥4 previous AEDs (47.9% [46–50], 823/1718). 1-year seizure-free rates were higher in those with 0–1 (20.6% [11–30], 14/68) and 2–3 previous AEDs (16.8% [11–23], 24/143) vs ≥4 previous AEDs (6.2% [4–8], 33/536). Adverse event rates were similar, with overlapping CIs (69.5% [61–78], 82/118; 69.0% [64–74], 191/277; 68.8% [66–71], 989/1438).

Conclusions Seizure freedom rates with perampanel use in routine practice are higher in epilepsy patients with <4 previously used AEDs than in those with 4 or more.

Authors/Disclosures
Eugen Trinka PRESENTER	Eugen Trinka has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. Eugen Trinka has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Eugen Trinka has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bial. Eugen Trinka has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GW Pharmaceuticals. The institution of Eugen Trinka has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Rapport. The institution of Eugen Trinka has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbott. The institution of Eugen Trinka has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Eugen Trinka has received research support from European Union. Eugen Trinka has received publishing royalties from a publication relating to health care.
	No disclosure on file
	No disclosure on file
	No disclosure on file

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