Abstract Details

Title Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping

Topic Movement Disorders

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-022

Objective Aimed to explore the inherent link of PD patients between their substantia nigra iron accumulation and clinical status using quantitative susceptibility mapping (QSM).

Background Iron deposition within the substantia nigra (SN) may play a vital role in Parkinson's disease (PD). However, owing to technological obstacles, we still don't know the interrelationship between brain iron content and the progression of PD. Quantitative susceptibility mapping (QSM) is a novel post- processing technique which has now been considered to be the only quantitative imaging technique of brain iron deposition.

Design/Methods 44 PD patients and 31 age- and gender-matched healthy controls underwent quantitative susceptibility mapping were recruited in this study. We firstly divided the patients into mild symptom severity (MSP) and advanced symptom severity (ASP) groups concerning their disease stage. Then, we classified the patients with Parkinson's disease into three subgroups: tremor-dominant PD (TD), akinetic/rigidity-dominant PD (AR), mixed- PD (M) according to their dominant motor symptoms.

Results Compared to healthy controls, patients with PD have increased QSM magnetic values in the substantia nigra. Besides, among the three clinical phenotypes both TD and AR subgroup showed significant difference compared with healthy controls concerning the QSM values. Furthermore, in MSP the significantly correlation was displayed only in MADRS, HAMA scores, when disease progressed into advanced severity stage all these clinical measures we had recruited into this study shown prominent correlation to SN iron content. In the three phenotypes the correlation between iron content and MADRS, HAMA scores were found in AR subgroups exclusively.

Conclusions ron accumulation in the SN is in line with Parkinson's disease progression. Furthermore, we testified that there are actually some inherent effects of substantia nigra iron deposition to the clinical symptoms of Parkinson's disease. Moreover, it seems that akinetic/ rigidity-dominant PD subgroup was affected most by SN iron accumulation.

Authors/Disclosures
Dongya Huang, MD (East Hospital) PRESENTER	No disclosure on file
	No disclosure on file

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