Abstract Details

Title Incidence and Predictors of Cerebral Venous Thrombosis (CVT) in Pregnancy: National Inpatient Sample Study 2012-2015

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S37 - Stroke Epidemiology: Risk Factors, Incidence, and Unique Populations (2:12 PM-2:24 PM)

Poster/Presentation
Number 007

Objective

This study investigates incidence and predictors of increased risk of CVT among hospitalized pregnant patients in United States.

Background Cerebral venous thrombosis (CVT) in pregnancy is often reported in the last trimester or shortly after delivery however, the incidence among pregnant women is not really known. In addition, information about predictors of increase risk of CVT among hospitalized pregnant patients is scarce.

Design/Methods

We performed a cross-sectional analysis using the Nationwide Inpatient Sample (NIS), 2012–2015, of US adult hospitalizations with pregnancy. Overall incidence of CVT was calculated using NIS weighting. We identified our CVT patient subset from using codes (ICD-9-CM Diagnosis codes: 4376, 325 and 6715) from the International Classification of Diseases, 9th edition. Potential factors associated with increased risk of CVT in pregnancy were assessed using logistic regression.

Results

Of 11,672,729 pregnant hospitalized patients, 1045 (0.01%) developed CVT during the index hospitalization. Important predictors of increased risk of CVT in pregnancy are: Age above 30 years (OR: 1.52, CI: 1.16-2.02 , p <.0001), coagulopathy (OR: 7.45, CI: 5.00-11.09 , p <.0001) and obesity (OR: 1.45, CI:1.16-2.02 , p= 0.0714).

Conclusions

Older age, coagulopathy and obesity are important predictors of increased risk of CVT in pregnant women. Availability of aggressive treatment has not modified significantly mortality which requires further study.

Authors/Disclosures
Huy Q. Nguyen, MD PRESENTER	No disclosure on file
Mohammad Rauf A. Chaudhry, MD	Dr. Chaudhry has nothing to disclose.
Saqib A. Chaudhry, MD	Dr. Chaudhry has nothing to disclose.
Shayan Ul Haque, MD, MBBS (RUSH Neuroscience)	No disclosure on file
Jiaqi Yao, MD (Baylor Scott and White)	Dr. Yao has nothing to disclose.
Harathi Bandaru, MD	Dr. Bandaru has nothing to disclose.
Arada Weerawat, MD (Northwell health system)	Dr. Wongmek has nothing to disclose.
Jorge H. Moreno, MD	No disclosure on file
Paisith Piriyawat, MD (Texas Tech University)	Dr. Piriyawat has nothing to disclose.
Salvador Cruz-Flores, MD, FAAN (Paul L. Foster School of Medicine Texas Tech University Health Sciences Center)	The institution of Dr. Cruz-Flores has received research support from University of Texas System.

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