Abstract Details

Title Parkinson’s disease Significantly Increases Variability of Day-to-Day activity patterns

Topic Movement Disorders

Presentation(s) P11 - Poster Session 11 (8:00 AM-9:00 AM)

Poster/Presentation
Number 3-005

Objective

To determine the changes in patterns of daily activity due to Parkinson’s disease (PD).

Background Daily activity is characterized by temporal fluctuations and is not exactly the same throughout the day nor between days. The impact of PD on this day-to-day variability of activity is not well established. Parkinson’s disease decreases the total amount of activity, but it is unclear if daily activity from day-to-day becomes more regular (because of medication intake and limited activity) or less regular (because patients suffer motor fluctuations, whose origins are unknown). This can affect the reliability of measurements with wearable sensors, which often provide information averaged over a few days.

Design/Methods 27 people with PD (69.3 ± 7.5 years old), 32 healthy elderly (66.1±8.3 years old), and 24 healthy young adults (24.3±3.5 years old) wore an activity monitor on the non-dominant wrist for seven days. Day-to-day regularity of activity was assessed using the Jensen-Shannon Divergence (JSD), a measure of similarity between probability distributions, applied across seven days. The activity was compared using Vector magnitudes that were calculated for different time windows (epochs) including 15-seconds, 30-second, 1-minute, 2-minute, 10-minute, 30-minute, and 1-hour.

Results

The PD group presented significantly higher JSD values (reduced similarity between days) and lower total amounts of daily activity compared to healthy elderly and healthy young. Total daily activity had a positive correlation with JSD values (similarity across days) for both PD and control with higher daily activity showing higher day-to-day similarity.

Conclusions Patients with PD have lower Day-to-day regularity of activity which seems to relate to the amount of physical activity in general. People with more regular patterns of activity are also more active. This suggests that daily routines may be important to enhance the total amount of activity and thus mobility in PD.

Change in day-to-day variability can affect at-home device-based measurements of PD.

Authors/Disclosures
Danish Bhatti, MD, FAAN (University of Central Florida College of Medicine) PRESENTER	Dr. Bhatti has nothing to disclose.
	No disclosure on file

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