Abstract Details

Title Liver Damage in High Blood Pressure Diseases in Pregnancy is related with Cognitive Capacity Decreasement

Topic General Neurology

Presentation(s) P16 - Poster Session 16 (5:30 PM-6:30 PM)

Poster/Presentation
Number 6-002

Objective Determine if there is a relation between the liver enzymes in blood and the congitive capacity in pregnancy high blood pressure diseases.

Background The high measurements of liver enzymes on the blood is a criteria for the diagnosis in preeclampsia. There is a relation between the cognitive capacity in liver diseases, but it hasn´t been studied if there is a relation among liver damage and congitive capacity in pregnancy high blood pressure diseases.

Design/Methods

Prospective study of patients with preeclampsia and eclampsia that entered the Gynecology and Obstetrics department of the Hospital Universitario “Dr. José E. González” during November 2018 and August 2019. MoCA and MMSE were made to evaluate cognitive capacity, and blood tests within the first 48 hours after giving birth.

Results 52 patients were included in the study, 35 (67.3%) with the diagnose of preeclampsia, 15 (28.8%) with eclampsia, and 2 (3.8%) with HELLP syndrome, with a medium age of 23.7 ± 6.7.The medium of the liver enzymes were aspartate transaminase (AST) 42.1 ± 53.4 U/L (15.4% value major than normal), alanine transaminase (ALT) 31.7 ± 48.5 U/L (value over the normal was 9.6%), alkaline phosphatase (ALP) 202.1 ± 82.9 U/L (88.5% over the normal) and lactate deshydrogenase (LDH) 274.8 ± 241.9 U/L (38.5% over the normal levels). MoCA had 31 (59.6%) and MMSE had 17 (32.7%) with cognitive deterioration. MoCA was correlated negatively with the values of AST (r=-0.420, p=0.002) and LDH (r=-0.422, p=0.003) and the MMSE was negatively correlated with AST (r=-0.460, p=0.001) and LDH (r=-0.379, p=0.008).

Conclusions This is the first study that makes a relation between cognitive capacity and the liver damage in pregnancy high blood pressure diseases. The results shows that higher than normal levels of AST and LDH, correlate with major cognitive affection in pregnant patients with high blood pressure diseases.

Authors/Disclosures
PRESENTER	No disclosure on file
Luis Fernandez (Neurology, University Hospital UANL)	No disclosure on file
	No disclosure on file
	No disclosure on file
Juan F. Gongora Rivera, MD, MD, MSc, PhD (Neurology and Stroke Unit, University Hospital UANL)	Dr. Gongora Rivera has nothing to disclose.

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