Epilepsy can have diverse and complex effects on the overall well-being or subjective quality of life (QOL) of its sufferers. Cognitive outcomes influence the quality of life of these patients.  Complex interaction between cognitive deficits and QOL, defending that the relationship between them should be assessed when one is treating Epilepsy patients. In this context it is worth stressing that: (a) in many individuals with Epilepsy QOL is more negatively affected by treatment side-effects than by the seizures themselves; and that (b) both the Epilepsy and its treatment can negatively affect cognition. The impact of epilepsy on a person's quality of life (QOL) may be significant because of profound adverse social, physical, and Psychological consequences of epilepsy and its treatments.

We found a significant association between Polytherapy, TLE and LRE with QOLIE-31 scores (p value being 0.0007 and <0.00001 respectively). We found a significant association between low MMSE scores and long duration of epilepsy more than 6 years ( p: 0.001 and 0.002), statistically highly significant association when compared with TLE and LRE (p: 0.000). MOCA showed strong positive correlation with QOLIE-31 scores when compared with MMSE.

Polytherapy, Long duration of Epilepsy, Temporal Lobe and other Focal Epilepsies, Poor Quality of Life standards are all independent factors determining the Cognitive dysfunction. There seems to be bidirectional relationship between Quality of Life and Cognitive dysfunction. MOCA seems to be superior to MMSE for Neurocognitive screening in PWE.