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Abstract Details

Structural Brain Patterns in Bilingual Versus Monolingual Persons with Alzheimer’s Disease
Aging, Dementia, and Behavioral Neurology
P3 - Poster Session 3 (12:00 PM-1:00 PM)
10-003
This work applied automated quantitative volumetric MR neuroimaging to characterizing specific patterns of brain volume loss in bilingual versus monolingual persons with Alzheimer’s dementia (AD).

With increased interest in determining factors that can modify risk of AD by increasing cognitive reserve, bilingualism is one such factor. However, brain biomarkers of bilingualism in AD are limited.

A total of 46 persons with AD from UCLA and either bilingual or monolingual status were evaluated by a Behavioral Neurologist with 20 years of experience. All subjects received a sagittal T1 weighted volumetric acquisition on a Siemens 3T MR scanner. All volumetric scans were analyzed by an FDA cleared volumetric algorithm, Neuroreader, that segmented and calculated brain volumes.

Of the 46 persons, 17 were bilingual and 21 were monolingual. The average age for the entire sample is 72.4 ± 11.6 years (Range: 53-95). 46% of the sample are women. There were no statistically significant differences between age and gender between bilingual and monolingual individuals. The following statistically significant or trending partial correlations were noted between bilingual status and the following brain volumes, when accounting for age, gender, and total head size: i) Ventral Diencephalon (r = .46, p = .002) ii) Pallidum (r = .31, p = .04) iii) Brainstem (r = .29, p = .05) and iv) Total Gray Matter (r = .29, p = .05). The hippocampus was larger in bilingual persons (r = .07, p = .6) but the relationship was not statistically significant.

Quantitative volumetric MR neuroimaging shows specific volumetric differences across persons with AD as a function of bilingual versus monolingual status. Several regions, such as the ventral diencephalon are novel compared to prior studies. Additional multi-modal imaging is needed to understand the relationship between bilingualism and cognitive reserve.

Authors/Disclosures
Cyrus A. Raji, MD, PhD (Washington University in St Louis)
PRESENTER 		Prof. Raji has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Brainreader ApS. Prof. Raji has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Apollo Health . Prof. Raji has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Neurevolution Medicine.
Somayeh Meysami, MD (Pacific Neuroscience Institute, Providence Saint Johns Health Center) Dr. Meysami has nothing to disclose.
Mario F. Mendez, MD, PhD, FAAN (VA Greater Los Angeles Healthcare System and UCLA) Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical 好色先生 Speakers' Bureau. Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for UpToDate. The institution of Dr. Mendez has received research support from NIH. Dr. Mendez has received publishing royalties from a publication relating to health care.