Abstract Details

Title Increased occurrence of migraine in perimenopausal aged women with stroke

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P3 - Poster Session 3 (12:00 PM-1:00 PM)

Poster/Presentation
Number 4-019

Objective Compare the co-occurrence of migraine in perimenopausal female, postmenopausal female, and male patients admitted with stroke to a tertiary care hospital.

Background The relationship between migraine and stroke, especially migraine with aura, has been well-established. Emerging evidence suggests that menopausal vasomotor symptoms increase the risk of cardiovascular and cerebrovascular disease, potentially highest during the perimenopausal period. The association between migraine and stroke in perimenopausal women versus age-matched men and postmenopausal women is uncertain.

Design/Methods Patient population data at a large tertiary care medical center was analyzed using the Epic SlicerDicer function. Diagnosis of migraine was compared in male (M) and female (F) patients aged 42-65 and female patients aged 70-100 with stroke admission between 3/17/2019 and 9/17/2019 using Chi-Square test.

Results Between 3/17/2019 and 9/17/2019, 460 patients aged 42-65 (M: n=265, 57.6%; F: n=195, 42.4%), and 276 female patients aged 70-100 were admitted with stroke. Of 53 aged 42-65 with migraine and stroke, the majority were female (F: n=38, 71.7%; M: n=15, 28.3%). Eleven women with stroke aged 70-100 had a migraine diagnosis. Perimenopausal aged women with stroke were more likely to have co-occurrence of migraine diagnosis than age-matched men (19.49% vs 5.66%, p<0.001) and postmenopausal aged women (19.49% vs 3.99%, p< 0.001).

Conclusions Perimenopausal aged female stroke patients were more likely than age matched male patients and postmenopausal aged female patients to have a diagnosis of migraine at a tertiary care hospital. This provides evidence that migraine may be a risk factor for stroke specifically in 42-65 year old women relative to male counterparts of the same age, or female counterparts of an older age. As this age range is consistent with perimenopause, additional research should be dedicated to studying this population to better understand the association of migraine, vasomotor symptoms, cardiovascular and cerebrovascular risk.

Authors/Disclosures
Morgan Figurelle, MD PRESENTER	Dr. Figurelle has nothing to disclose.
Crystal Sosa, MD (HHC)	Dr. Sosa has nothing to disclose.
Rebecca E. Wells, MD, FAAN (Wake Forest Bapttist Medical Center)	The institution of Dr. Wells has received research support from NIH. Dr. Wells has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Southern Headache Society. Dr. Wells has a non-compensated relationship as a Board member with Southern Headache Society that is relevant to AAN interests or activities. Dr. Wells has a non-compensated relationship as a Board member with American Headache Society that is relevant to AAN interests or activities.
Amy K. Guzik, MD, FAAN (Wake Forest University Baptist Medical Center)	Dr. Guzik has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Local law firms, available by request.

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