Abstract Details

Title EEG reactivity predicts outcomes in cardiac arrest patients.

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P5 - Poster Session 5 (8:00 AM-9:00 AM)

Poster/Presentation
Number 12-011

Objective To evaluate EEG reactivity (EEG-R) in prediction of outcomes and improvement in Neurological examination in post cardiac arrest patients.

Background The presence of EEG-R is linked to better odds of survival. However, there is a lack of studies using standardized methods for EEG-R and determining the survival outcomes and improvement of neurological examination in cardiac arrest patients. We instituted a protocol for EEG-R in these patients and assessed changes in their clinical examination.

Design/Methods We retrospectively reviewed our prospectively maintained EEG database for cardiac arrest patients over a 6 month period. EEG-R was assessed daily using a stepwise approach of verbal, photic, tactile and peripheral and central noxious stimulus as we have previously presented (Zubairi et al. AAN, 2018). EEG reactivity was determined by an Epileptologist uninvolved in the patient care. Patients neurological assessment data during hospitalization and cerebral performance category (CPC) scores at 3 months were collected. We analyzed our patient EEG-R using standard Fischer test and Chi square.

Results 61 cardiac patients (mean age 65years; 28M:22F) were included in this study. 43 patients had EEG-R data. EEG-R was significantly associated with the survival of the patients (11 vs 3) in comparison to patients who did not have EEG-R (8 vs 21); p=0.002. EEG-R was associated with command following during hospital stay (71% vs 0%); p: 0.0001. The mean CPC at discharge for patients having EEG-R was 3.21±0.51 vs 4.76±0.44 (p=0.0001) for patients with no EEG-R. The sensitivity of EEG-R for survival prediction was 58% and the specificity was 87% in our study. The sensitivity for 3 months good outcomes (CPC 3 or less) was 46% and specificity was 100%.

Conclusions

Absence of EEG-R is predictive of hospital survival as well as 3 months outcomes with high specificity.

Authors/Disclosures
Vikram Bhinder, MD (University of Toledo) PRESENTER	No disclosure on file
Stephen Hantus, MD (Cleveland Clinic)	Dr. Hantus has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Hantus has received personal compensation in the range of $0-$499 for serving as a Consultant for UCB.
Vineet Punia, MD (Cleveland Clinic)	Dr. Punia has nothing to disclose.
Christopher R. Newey, DO (Sanford Health)	Dr. Newey has nothing to disclose.

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