Abstract Details

Title Characterizing Changes in Sensorimotor Integration after Chronic Stroke Based on Neural Activity and Movement Kinematics

Topic Neuro-rehabilitation

Presentation(s) P7 - Poster Session 7 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-011

Objective To determine how neural activity encoding different instructional information and movement information changes after motor function is regained post-stroke.

Background After a stroke, some patients might initially have impaired arm function which is regained during rehabilitation. Clinical assessments (e.g. Fugl-Meyer) are able to characterize the overall quality of motor function, however these assessments might not capture subtle variations or deficits in motor production. Characterizing how different aspects of sensorimotor integration changes in post-stroke neural activity or movement kinematics is important to understand how the nervous system changes when regaining motor function.

Design/Methods Healthy participants and chronic stroke patients performed a complex object-manipulation task in which different visual or auditory stimuli instructed specific objects to be manipulated. Mobile brain/body imaging (MOBI) techniques were used to record neural activity using electroencephalography (EEG) and arm kinematics using a motion capture system. Event-related potentials (ERPs) of neural activity were measured, aligned on the time on instruction delivery, for trials involving each of the different instruction types. Kinematic trajectories of the arm were measured to characterize changes based on the different instructions.

Results Twenty healthy participants (ages 19-72) and three stroke patients (ages 21-77) performed the task. Patients had initial arm weakness at stroke onset and were at least 3 months post-stroke. Reaction and movement times were significantly slower for patient group (p<0.05, ANOVA). ERPs related to auditory instructions were greater than for visual instructions. Although the patient cohort was small, differences were detected in the neural activity and movement kinematics compared to healthy controls.

Conclusions Neural activity differentiated aspects of sensorimotor integration in healthy controls and patients. MOBI techniques characterized subtle differences in motor performance. Future work will determine how different aspects of stroke relate to motor performance with a larger patient cohort. Such study will aid in developing therapeutic solutions that rehabilitate function more efficiently.

Authors/Disclosures
Kevin A. Mazurek, PhD (Mayo Clinic) PRESENTER	Dr. Mazurek has received personal compensation for serving as an employee of Delos Living / Well Living Lab. Dr. Mazurek has received intellectual property interests from a discovery or technology relating to health care. An immediate family member of Dr. Mazurek has a non-compensated relationship as a Editor with AAN Resident and Fellows Section that is relevant to AAN interests or activities.
	No disclosure on file
	No disclosure on file
	No disclosure on file
David P. Richardson	No disclosure on file
	No disclosure on file
Ania Busza, MD, PhD (University of Rochester)	Dr. Busza has received research support from NIH/NINDS. Dr. Busza has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH.
	No disclosure on file
	No disclosure on file

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