Abstract Details

Title Race and Ethnicity Influence Perihematomal Edema Volume in Supratentorial Intracerebral Hemorrhage

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S30 - Cerebrovascular Disease and Interventional Neurology 3 (4:08 PM-4:16 PM)

Poster/Presentation
Number 002

Objective To evaluate whether race and ethnicity influence baseline Perihematomal Edema (PHE) volume in patients with spontaneous, non-traumatic intracerebral hemorrhage (ICH).

Background PHE is a neuroimaging biomarker of secondary brain injury in patients with ICH. There are limited data on racial/ethnic differences in the development of PHE. This dearth of data is partially driven by the time-consuming process of manually segmenting PHE.

Design/Methods The Ethnic/Racial Variations in Intracerebral Hemorrhage (ERICH) study is a prospective, multicenter study of ICH that recruited 1,000 adult participants from each of three racial/ethnic groups (non-Hispanic White, non-Hispanic Black, and Hispanic). We applied a previously validated deep learning algorithm to automatically determine PHE volumes on baseline CTs in these study participants. Quality control procedures were used to include only sufficiently accurate PHE measurements. Linear regression was used to identify factors associated with log-transformed PHE volume and to identify differences across Ethnic/Racial groups.

Results Our imaging pipeline provided good quality baseline PHE measurements on 2,008 out of 3,000 ERICH study participants. After excluding infratentorial hemorrhages (273) and those with missing or null baseline ICH volume (49), 1,686 remained for analysis (median age 59 [IQR 51-71], 687 [41%] female sex). Median PHE volume was 12.0 (IQR 4.8-27.1) for Whites, 11.9 (IQR 4.5-26.1) for Hispanics and 8.3 (IQR 3.0-19.2) for Blacks. Compared to Blacks, Hispanics (beta 0.21; 95%CI 0.08-0.33; p=0.001) and Whites (beta 0.20; 95%CI 0.06-0.34; p=0.005) had higher baseline PHE volumes, in multivariable analysis adjusting for age, sex, time to CT, ICH location, log-baseline ICH volume, log-baseline intraventricular volume, and systolic blood pressure on admission.

Conclusions Race and ethnicity influence the volume of baseline PHE. Further studies are needed to validate our results and investigate the biological underpinnings of this difference.

Authors/Disclosures
Julian Acosta, MD (Yale) PRESENTER	Dr. Acosta has nothing to disclose.
	No disclosure on file
	No disclosure on file
Audrey Leasure	Ms. Leasure has nothing to disclose.
Fernando D. Testai, MD, PhD, FAAN (University of Illinois at Chicago)	Dr. Testai has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Testai has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Livingston, Barger, Brandt & Schroeder, L.L.P.. Dr. Testai has received publishing royalties from a publication relating to health care.
Daniel Woo, MD, FAAN (University at Buffalo)	The institution of Dr. Woo has received research support from NIH.
Jin M. Lee, MD, PhD (Washington University School of Medicine)	No disclosure on file
Kevin N. Sheth, MD, FAAN (Yale UniversityDivision of Neuro and Critical Care)	Dr. Sheth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ceribell. Dr. Sheth has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Zoll. Dr. Sheth has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NControl. Dr. Sheth has received stock or an ownership interest from Astrocyte. Dr. Sheth has received stock or an ownership interest from Alva. The institution of Dr. Sheth has received research support from Biogen. The institution of Dr. Sheth has received research support from Novartis. The institution of Dr. Sheth has received research support from Bard. The institution of Dr. Sheth has received research support from Hyperfine. Dr. Sheth has received intellectual property interests from a discovery or technology relating to health care.
Rajat Dhar, MD (Washington University in St. Louis School of Medicine)	Dr. Dhar has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Mid-America Transplant. Dr. Dhar has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for UCB Pharma. The institution of Dr. Dhar has received research support from NINDS.
Guido J. Falcone, MD (Yale School of Medicine)	The institution of Dr. Falcone has received research support from NIH. The institution of Dr. Falcone has received research support from AHA.

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