Six cases of anti LGI1 encephalitis ( 3 females , 3 males ) were recruited. Age varied between 22 and 62.Mean duration of presentation to hospital was 22 days. 83%(5/6) had Faciobrachial dystonic seizures (FBDS) and one patient had paroxysmal kinesogenic dyskinesia with episodic piloerection. 33 %(2/6) had encephalopathy, episodic memory disturbances, hyponatremia and CSF pleocytosis. One patient had CPS. Two patients had sleep disturbance. EEG showed theta slowing in 50%, no epileptiform activity seen.83% patients showed MRI changes of limbic encephalitis.
All received 5 pulses of 1g IV methylprednisolone followed by oral wysolone 1mg/kg. Remission achievement varied from 2 weeks to 4weeks. Oral steroids were tapered and stopped between a period of 5 to 7 months. Azathioprine 2mg/kg was given along with steroid to 5/6patients.Azathioprine was stopped at the end of 1 year. No patient received IVIG or PLEX .Patients also received AEDS (Oxcarbazepine 4/6, valproate 2/6 and Clonazepam 4/6).One patient received Risperidone a. AEDs were tapered in 6 months in all except the one with seizure where it was tapered after 1 year .No relapses were seen .Post treatment remission periods varies between 3 months and 2 years