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Abstract Details

Analysis of ALS Biospecimen Demand and Utilization of Samples for the National ALS Biorepository
General Neurology
General Neurology Posters (7:00 AM-5:00 PM)
049
To help ensure the usefulness of the National ALS Biorepository, a biospecimen demand analysis is conducted on an annual basis, as well as an analysis of the utilization of the biorepository.
Amyotrophic lateral sclerosis (ALS) is a rare neurological condition affecting upper and lower motor neurons. The National ALS Biorepository, a repository for biospecimens for future ALS research, launched in 2015, and specimen collection began in 2017. 
To determine the types of biospecimens to be collected for the biorepository, an in-depth initial analysis occurred, followed by ongoing specimen demand and utilization analyses. The initial examination included analysis from an expert panel, discussions with ALS research experts, review of other ALS biorepositories, assessment of specimen demand, and analysis of the specimen types historically used in ALS research. 
Of all biospecimen types reported in the literature, the most frequently used were DNA, postmortem spinal cord, blood, and cerebrospinal fluid; while the most frequently reported types of specimens used in ALS-related grants were induced pluripotent stem cells (iPSCs), brain, blood, and spinal cord.

Continuous analysis of potential sample demand and tissues collected, based on an analysis of the literature and funded grants, and actual sample requests can assist the Biorepository to ensure the appropriate samples are available for researchers at the time they are needed. 

Authors/Disclosures

PRESENTER 		No disclosure on file
Lindsay Rechtman The institution of Lindsay Rechtman has received research support from ATSDR.
Laurie Wagner (McKing Consulting Corporation) Laurie Wagner has nothing to disclose.
Paul Mehta Paul Mehta has nothing to disclose.
D Kevin Horton No disclosure on file
Moon Han, PhD (Agency for Toxic Substances and Disease Registry) Dr. Han has nothing to disclose.
Wendy E. Kaye, PhD (McKing Consulting Corp) Dr. Kaye has received personal compensation for serving as an employee of McKing Consulting Corporation. Dr. Kaye has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Association for the Protection of Human Research Participants.